2a4g

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[[Image:2a4g.gif|left|200px]]
[[Image:2a4g.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2a4g |SIZE=350|CAPTION= <scene name='initialview01'>2a4g</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2a4g", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=UNH:({1-[1-CARBAMOYL-PHENYL-METHYL)-CARBAMOYL]-METHYL}-AMINOOXALYL)-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL)-CYCLOHEXYL-METHYL)-CARBAMIC+ACID+ISOBUTYL+ESTER'>UNH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2a4g| PDB=2a4g | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4g OCA], [http://www.ebi.ac.uk/pdbsum/2a4g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a4g RCSB]</span>
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}}
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'''Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound'''
'''Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound'''
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[[Category: Yao, N.]]
[[Category: Yao, N.]]
[[Category: Zhu, Z.]]
[[Category: Zhu, Z.]]
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[[Category: virus/viral protein]]
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[[Category: Virus/viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:35:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:47:44 2008''
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Revision as of 15:35, 3 May 2008

Image:2a4g.gif

Template:STRUCTURE 2a4g

Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound


Overview

We have discovered that introduction of appropriate amino acid derivatives at P'2 position improved the binding potency of P3-capped alpha-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound to the protease revealed the importance of the P'2 moiety.

About this Structure

2A4G is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency., Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK, Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. PMID:16087332 Page seeded by OCA on Sat May 3 18:35:22 2008

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OCA

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