2a5x

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[[Image:2a5x.gif|left|200px]]
[[Image:2a5x.gif|left|200px]]
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{{Structure
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|PDB= 2a5x |SIZE=350|CAPTION= <scene name='initialview01'>2a5x</scene>, resolution 2.49&Aring;
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The line below this paragraph, containing "STRUCTURE_2a5x", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LAR:LATRUNCULIN+A'>LAR</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NSB:N,N,N-TRIMETHYL-3-SULFOPROPAN-1-AMINIUM'>NSB</scene>
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{{STRUCTURE_2a5x| PDB=2a5x | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a5x OCA], [http://www.ebi.ac.uk/pdbsum/2a5x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a5x RCSB]</span>
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'''Crystal Structure of a Cross-linked Actin Dimer'''
'''Crystal Structure of a Cross-linked Actin Dimer'''
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[[Category: Sawaya, M R.]]
[[Category: Sawaya, M R.]]
[[Category: Yeates, T O.]]
[[Category: Yeates, T O.]]
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[[Category: muscle protein]]
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[[Category: Muscle protein]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:38:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:48:17 2008''
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Revision as of 15:38, 3 May 2008

Image:2a5x.gif

Template:STRUCTURE 2a5x

Crystal Structure of a Cross-linked Actin Dimer


Overview

The 2.5-A resolution crystal structure is reported for an actin dimer, composed of two protomers cross-linked along the longitudinal (or vertical) direction of the F-actin filament. The crystal structure provides an atomic resolution view of a molecular interface between actin protomers, which we argue represents a near-native interaction in the F-actin filament. The interaction involves subdomains 3 and 4 from distinct protomers. The atomic positions in the interface visualized differ by 5-10 A from those suggested by previous models of F-actin. Such differences fall within the range of uncertainties allowed by the fiber diffraction and electron microscopy methods on which previous models have been based. In the crystal, the translational arrangement of protomers lacks the slow twist found in native filaments. A plausible model of F-actin can be constructed by reintroducing the known filament twist, without disturbing significantly the interface observed in the actin dimer crystal.

About this Structure

2A5X is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a cross-linked actin dimer suggests a detailed molecular interface in F-actin., Kudryashov DS, Sawaya MR, Adisetiyo H, Norcross T, Hegyi G, Reisler E, Yeates TO, Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13105-10. Epub 2005 Sep 1. PMID:16141336 Page seeded by OCA on Sat May 3 18:38:53 2008

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