2a64

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[[Image:2a64.gif|left|200px]]
[[Image:2a64.gif|left|200px]]
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{{Structure
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|PDB= 2a64 |SIZE=350|CAPTION= <scene name='initialview01'>2a64</scene>, resolution 3.300&Aring;
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The line below this paragraph, containing "STRUCTURE_2a64", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_2a64| PDB=2a64 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a64 OCA], [http://www.ebi.ac.uk/pdbsum/2a64 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a64 RCSB]</span>
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'''Crystal Structure of Bacterial Ribonuclease P RNA'''
'''Crystal Structure of Bacterial Ribonuclease P RNA'''
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[[Category: Krivenko, A A.]]
[[Category: Krivenko, A A.]]
[[Category: Pace, N R.]]
[[Category: Pace, N R.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: ribonuclease]]
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[[Category: Ribonuclease]]
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[[Category: ribozyme]]
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[[Category: Ribozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:39:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Apr 1 09:01:25 2008''
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Revision as of 15:39, 3 May 2008

Image:2a64.gif

Template:STRUCTURE 2a64

Crystal Structure of Bacterial Ribonuclease P RNA


Overview

The x-ray crystal structure of a 417-nt ribonuclease P RNA from Bacillus stearothermophilus was solved to 3.3-A resolution. This RNA enzyme is constructed from a number of coaxially stacked helical domains joined together by local and long-range interactions. These helical domains are arranged to form a remarkably flat surface, which is implicated by a wealth of biochemical data in the binding and cleavage of the precursors of transfer RNA substrate. Previous photoaffinity crosslinking data are used to position the substrate on the crystal structure and to identify the chemically active site of the ribozyme. This site is located in a highly conserved core structure formed by intricately interlaced long-range interactions between interhelical sequences.

About this Structure

2A64 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Crystal structure of a bacterial ribonuclease P RNA., Kazantsev AV, Krivenko AA, Harrington DJ, Holbrook SR, Adams PD, Pace NR, Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13392-7. Epub 2005 Sep 12. PMID:16157868 Page seeded by OCA on Sat May 3 18:39:18 2008

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