2a6r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2a6r.gif|left|200px]]
[[Image:2a6r.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2a6r |SIZE=350|CAPTION= <scene name='initialview01'>2a6r</scene>, resolution 2.05&Aring;
+
The line below this paragraph, containing "STRUCTURE_2a6r", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= yoeB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2a6r| PDB=2a6r | SCENE= }}
-
|RELATEDENTRY=[[2a6q|2A6Q]], [[2a6s|2A6S]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a6r OCA], [http://www.ebi.ac.uk/pdbsum/2a6r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a6r RCSB]</span>
+
-
}}
+
'''Crystal structure of YoeB under PEG condition'''
'''Crystal structure of YoeB under PEG condition'''
Line 27: Line 24:
[[Category: Hanaoka, F.]]
[[Category: Hanaoka, F.]]
[[Category: Kamada, K.]]
[[Category: Kamada, K.]]
-
[[Category: addiction module]]
+
[[Category: Addiction module]]
-
[[Category: antitoxin]]
+
[[Category: Antitoxin]]
-
[[Category: inhibitor]]
+
[[Category: Inhibitor]]
-
[[Category: rnase]]
+
[[Category: Rnase]]
-
[[Category: toxin]]
+
[[Category: Toxin]]
-
[[Category: yefm]]
+
[[Category: Yefm]]
-
[[Category: yoeb]]
+
[[Category: Yoeb]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:40:47 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:48:33 2008''
+

Revision as of 15:40, 3 May 2008

Image:2a6r.gif

Template:STRUCTURE 2a6r

Crystal structure of YoeB under PEG condition


Overview

The eubacterial chromosome encodes various addiction modules that control global levels of translation through RNA degradation. Crystal structures of the Escherichia coli YefM2 (antitoxin)-YoeB (toxin) complex and the free YoeB toxin have been determined. The structure of the heterotrimeric complex reveals an asymmetric disorder-to-order recognition strategy, in which one C terminus of the YefM homodimer exclusively interacts with an atypical microbial ribonuclease (RNase) fold of YoeB. Comparison with the YefM-free YoeB structure indicates a conformational rearrangement of the RNase catalytic site of YoeB, induced by interaction with YefM. Complementary biochemical experiments demonstrate that the YoeB toxin has an in vitro RNase activity that preferentially cleaves at the 3' end of purine ribonucleotides.

About this Structure

2A6R is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin., Kamada K, Hanaoka F, Mol Cell. 2005 Aug 19;19(4):497-509. PMID:16109374 Page seeded by OCA on Sat May 3 18:40:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2a6r"
Personal tools