2a79

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[[Image:2a79.gif|left|200px]]
[[Image:2a79.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2a79 |SIZE=350|CAPTION= <scene name='initialview01'>2a79</scene>, resolution 2.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2a79", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>
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|ACTIVITY=
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|GENE= Kcnab2, Ckbeta2, Kcnb3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), Kcna2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_2a79| PDB=2a79 | SCENE= }}
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|RELATEDENTRY=[[1exb|1EXB]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a79 OCA], [http://www.ebi.ac.uk/pdbsum/2a79 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a79 RCSB]</span>
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}}
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'''Mammalian Shaker Kv1.2 potassium channel- beta subunit complex'''
'''Mammalian Shaker Kv1.2 potassium channel- beta subunit complex'''
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[[Category: Long, S B.]]
[[Category: Long, S B.]]
[[Category: MacKinnon, R.]]
[[Category: MacKinnon, R.]]
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[[Category: eukaryotic]]
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[[Category: Eukaryotic]]
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[[Category: ion channel]]
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[[Category: Ion channel]]
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[[Category: kv1 2]]
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[[Category: Kv1 2]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: potassium channel]]
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[[Category: Potassium channel]]
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[[Category: shaker]]
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[[Category: Shaker]]
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[[Category: voltage dependent]]
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[[Category: Voltage dependent]]
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[[Category: voltage sensor]]
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[[Category: Voltage sensor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:41:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:48:45 2008''
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Revision as of 15:41, 3 May 2008

Image:2a79.gif

Template:STRUCTURE 2a79

Mammalian Shaker Kv1.2 potassium channel- beta subunit complex


Overview

Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase beta subunit of the kind that can regulate mammalian Kv channels in their native cell environment. The activation gate of the pore is open. Large side portals communicate between the pore and the cytoplasm. Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit.

About this Structure

2A79 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel., Long SB, Campbell EB, Mackinnon R, Science. 2005 Aug 5;309(5736):897-903. Epub 2005 Jul 7. PMID:16002581 Page seeded by OCA on Sat May 3 18:41:54 2008

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