2a8h

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[[Image:2a8h.gif|left|200px]]
[[Image:2a8h.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2a8h |SIZE=350|CAPTION= <scene name='initialview01'>2a8h</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2a8h", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=4NH:4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE'>4NH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ADAM17, CSVP, TACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2a8h| PDB=2a8h | SCENE= }}
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|RELATEDENTRY=[[1bkc|1bkc]], [[1zxc|1ZXC]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a8h OCA], [http://www.ebi.ac.uk/pdbsum/2a8h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a8h RCSB]</span>
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}}
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'''Crystal structure of catalytic domain of TACE with Thiomorpholine Sulfonamide Hydroxamate inhibitor'''
'''Crystal structure of catalytic domain of TACE with Thiomorpholine Sulfonamide Hydroxamate inhibitor'''
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[[Category: Xu, J.]]
[[Category: Xu, J.]]
[[Category: Xu, W.]]
[[Category: Xu, W.]]
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[[Category: tace-inhibitor complex]]
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[[Category: Tace-inhibitor complex]]
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[[Category: tace/adam-17]]
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[[Category: Tace/adam-17]]
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[[Category: zn-endopeptidase]]
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[[Category: Zn-endopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:44:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:49:14 2008''
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Revision as of 15:44, 3 May 2008

Image:2a8h.gif

Template:STRUCTURE 2a8h

Crystal structure of catalytic domain of TACE with Thiomorpholine Sulfonamide Hydroxamate inhibitor


Overview

A series of thiomorpholine sulfonamide hydroxamate TACE inhibitors, all bearing propargylic ether P1' groups, was explored. In particular, compound 5h has excellent in vitro potency against isolated TACE enzyme and in cells, oral activity in a model of TNF-alpha production and a collagen-induced arthritis model, was selected as a clinical candidate for the treatment of RA.

About this Structure

2A8H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates., Levin JI, Chen JM, Laakso LM, Du M, Schmid J, Xu W, Cummons T, Xu J, Jin G, Barone D, Skotnicki JS, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1605-9. Epub 2006 Jan 19. PMID:16426848 Page seeded by OCA on Sat May 3 18:44:38 2008

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OCA

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