2aat

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[[Image:2aat.jpg|left|200px]]
[[Image:2aat.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2aat |SIZE=350|CAPTION= <scene name='initialview01'>2aat</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_2aat", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PMP:4&#39;-DEOXY-4&#39;-AMINOPYRIDOXAL-5&#39;-PHOSPHATE'>PMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2aat| PDB=2aat | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aat OCA], [http://www.ebi.ac.uk/pdbsum/2aat PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2aat RCSB]</span>
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}}
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'''2.8-ANGSTROMS-RESOLUTION CRYSTAL STRUCTURE OF AN ACTIVE-SITE MUTANT OF ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI'''
'''2.8-ANGSTROMS-RESOLUTION CRYSTAL STRUCTURE OF AN ACTIVE-SITE MUTANT OF ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI'''
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[[Category: Smith, D.]]
[[Category: Smith, D.]]
[[Category: Toney, M.]]
[[Category: Toney, M.]]
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[[Category: transferase(aminotransferase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:49:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:50:13 2008''
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Revision as of 15:49, 3 May 2008

Image:2aat.jpg

Template:STRUCTURE 2aat

2.8-ANGSTROMS-RESOLUTION CRYSTAL STRUCTURE OF AN ACTIVE-SITE MUTANT OF ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI


Overview

The three-dimensional structure of a mutant of the aspartate aminotransferase from Escherichia coli, in which the active-site lysine has been substituted by alanine (K258A), has been determined at 2.8-A resolution by X-ray diffraction. The mutant enzyme contains pyridoxamine phosphate as cofactor. The structure is compared to that of the mitochondrial aspartate aminotransferase. The most striking differences, aside from the absence of the lysine side chain, occur in the positions of the pyridoxamine group and of tryptophan 140.

About this Structure

2AAT is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

2.8-A-resolution crystal structure of an active-site mutant of aspartate aminotransferase from Escherichia coli., Smith DL, Almo SC, Toney MD, Ringe D, Biochemistry. 1989 Oct 3;28(20):8161-7. PMID:2513875 Page seeded by OCA on Sat May 3 18:49:34 2008

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