2ac1

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[[Image:2ac1.gif|left|200px]]
[[Image:2ac1.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ac1 |SIZE=350|CAPTION= <scene name='initialview01'>2ac1</scene>, resolution 2.15&Aring;
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The line below this paragraph, containing "STRUCTURE_2ac1", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-fructofuranosidase Beta-fructofuranosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.26 3.2.1.26] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= At3g13790 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])
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|DOMAIN=
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{{STRUCTURE_2ac1| PDB=2ac1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ac1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ac1 OCA], [http://www.ebi.ac.uk/pdbsum/2ac1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ac1 RCSB]</span>
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}}
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'''Crystal structure of a cell-wall invertase from Arabidopsis thaliana'''
'''Crystal structure of a cell-wall invertase from Arabidopsis thaliana'''
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[[Category: Roy, K Le.]]
[[Category: Roy, K Le.]]
[[Category: Verhaest, M.]]
[[Category: Verhaest, M.]]
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[[Category: five fold beta propeller]]
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[[Category: Five fold beta propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:51:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:50:43 2008''
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Revision as of 15:51, 3 May 2008

Image:2ac1.gif

Template:STRUCTURE 2ac1

Crystal structure of a cell-wall invertase from Arabidopsis thaliana


Overview

Cell-wall invertases play crucial roles during plant development. They hydrolyse sucrose into its fructose and glucose subunits by cleavage of the alpha1-beta2 glycosidic bond. Here, the structure of the Arabidopsis thaliana cell-wall invertase 1 (AtcwINV1; gene accession code At3g13790) is described at a resolution of 2.15 A. The structure comprises an N-terminal fivefold beta-propeller domain followed by a C-terminal domain formed by two beta-sheets. The active site is positioned in the fivefold beta-propeller domain, containing the nucleophile Asp23 and the acid/base catalyst Glu203 of the double-displacement enzymatic reaction. The function of the C-terminal domain remains unknown. Unlike in other GH 32 family enzyme structures known to date, in AtcwINV1 the cleft formed between both domains is blocked by Asn299-linked carbohydrates. A preliminary site-directed mutagenesis experiment (Asn299Asp) removed the glycosyl chain but did not alter the activity profile of the enzyme.

About this Structure

2AC1 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

X-ray diffraction structure of a cell-wall invertase from Arabidopsis thaliana., Verhaest M, Lammens W, Le Roy K, De Coninck B, De Ranter CJ, Van Laere A, Van den Ende W, Rabijns A, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1555-63. Epub 2006, Nov 23. PMID:17139091 Page seeded by OCA on Sat May 3 18:51:55 2008

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