2acx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2acx.gif|left|200px]]
[[Image:2acx.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2acx |SIZE=350|CAPTION= <scene name='initialview01'>2acx</scene>, resolution 2.60&Aring;
+
The line below this paragraph, containing "STRUCTURE_2acx", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= GRK6, GPRK6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2acx| PDB=2acx | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2acx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2acx OCA], [http://www.ebi.ac.uk/pdbsum/2acx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2acx RCSB]</span>
+
-
}}
+
'''Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP'''
'''Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP'''
Line 29: Line 26:
[[Category: Tesmer, J J.]]
[[Category: Tesmer, J J.]]
[[Category: Tesmer, V M.]]
[[Category: Tesmer, V M.]]
-
[[Category: g protein]]
+
[[Category: G protein]]
-
[[Category: g protein coupled receptor kinase]]
+
[[Category: G protein coupled receptor kinase]]
-
[[Category: grk]]
+
[[Category: Grk]]
-
[[Category: grk6]]
+
[[Category: Grk6]]
-
[[Category: kinase]]
+
[[Category: Kinase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:53:28 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:50:55 2008''
+

Revision as of 15:53, 3 May 2008

Image:2acx.gif

Template:STRUCTURE 2acx

Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP


Overview

We describe the 2.6-A crystal structure of human G protein-coupled receptor kinase (GRK)-6, a key regulator of dopaminergic signaling and lymphocyte chemotaxis. GRK6 is a member of the GRK4 subfamily of GRKs, which is represented in most, if not all, metazoans. Comparison of GRK6 with GRK2 confirms that the catalytic core of all GRKs consists of intimately associated kinase and regulator of G protein signaling (RGS) homology domains. Despite being in complex with an ATP analog, the kinase domain of GRK6 remains in an open, presumably inactive conformation, suggesting that G protein-coupled receptors activate GRKs by inducing kinase domain closure. The structure reveals a putative phospholipid-binding site near the N terminus of GRK6 and structural elements within the kinase substrate channel that likely influence G protein-coupled receptor access and specificity. The crystalline GRK6 RGS homology domain forms an extensive dimer interface using conserved hydrophobic residues distinct from those in GRK2 that bind Galpha(q), although dimerization does not appear to occur in solution and is not required for receptor phosphorylation.

About this Structure

2ACX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs., Lodowski DT, Tesmer VM, Benovic JL, Tesmer JJ, J Biol Chem. 2006 Jun 16;281(24):16785-93. Epub 2006 Apr 13. PMID:16613860 Page seeded by OCA on Sat May 3 18:53:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2acx"
Personal tools