2ahj

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[[Image:2ahj.gif|left|200px]]
[[Image:2ahj.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ahj |SIZE=350|CAPTION= <scene name='initialview01'>2ahj</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_2ahj", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=1:In+Chain+C'>1</scene>, <scene name='pdbsite=CTA:Non-Heme+Fe+Center+And+Catalytic+Site+Site_description+I+...'>CTA</scene> and <scene name='pdbsite=CTB:In+Chain+A+Site_identifier+Ctb+Site_description+Non-Heme+...'>CTB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NO:NITROGEN+OXIDE'>NO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrile_hydratase Nitrile hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.84 4.2.1.84] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2ahj| PDB=2ahj | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ahj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahj OCA], [http://www.ebi.ac.uk/pdbsum/2ahj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ahj RCSB]</span>
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}}
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'''NITRILE HYDRATASE COMPLEXED WITH NITRIC OXIDE'''
'''NITRILE HYDRATASE COMPLEXED WITH NITRIC OXIDE'''
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[[Category: Tsujimura, M.]]
[[Category: Tsujimura, M.]]
[[Category: Yohda, M.]]
[[Category: Yohda, M.]]
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[[Category: hydratase]]
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[[Category: Hydratase]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: nitric oxide binding enzyme]]
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[[Category: Nitric oxide binding enzyme]]
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[[Category: non-heme iron center]]
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[[Category: Non-heme iron center]]
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[[Category: photoreactive enzyme]]
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[[Category: Photoreactive enzyme]]
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[[Category: post-translational modification of cysteine residue]]
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[[Category: Post-translational modification of cysteine residue]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:03:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:52:44 2008''
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Revision as of 16:03, 3 May 2008

Template:STRUCTURE 2ahj

NITRILE HYDRATASE COMPLEXED WITH NITRIC OXIDE


Overview

The iron-containing nitrile hydratase (NHase) is a photoreactive enzyme that is inactivated in the dark because of persistent association with NO and activated by photo-dissociation of NO. The crystal structure at 1.7 A resolution and mass spectrometry revealed the structure of the non-heme iron catalytic center in the nitrosylated state. Two Cys residues coordinated to the iron were post-translationally modified to Cys-sulfenic and -sulfinic acids. Together with another oxygen atom of the Ser ligand, these modifications induced a claw setting of oxygen atoms capturing an NO molecule. This unprecedented structure is likely to enable the photo-regulation of NHase and will provide an excellent model for designing photo-controllable chelate complexes and, ultimately, proteins.

About this Structure

2AHJ is a Protein complex structure of sequences from Rhodococcus erythropolis. Full crystallographic information is available from OCA.

Reference

Novel non-heme iron center of nitrile hydratase with a claw setting of oxygen atoms., Nagashima S, Nakasako M, Dohmae N, Tsujimura M, Takio K, Odaka M, Yohda M, Kamiya N, Endo I, Nat Struct Biol. 1998 May;5(5):347-51. PMID:9586994 Page seeded by OCA on Sat May 3 19:03:26 2008

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