2ai2

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[[Image:2ai2.gif|left|200px]]
[[Image:2ai2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ai2 |SIZE=350|CAPTION= <scene name='initialview01'>2ai2</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_2ai2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P1D:((2S,3AS,4R,6S)-4-(HYDROXYMETHYL)-6-(4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-TETRAHYDROFURO[3,4-D][1,3]DIOXOL-2-YL)METHYLPHOSPHONIC+ACID'>P1D</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2ai2| PDB=2ai2 | SCENE= }}
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|RELATEDENTRY=[[2ai1|2AI1]], [[2ai3|2AI3]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ai2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ai2 OCA], [http://www.ebi.ac.uk/pdbsum/2ai2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ai2 RCSB]</span>
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}}
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'''Purine nucleoside phosphorylase from calf spleen'''
'''Purine nucleoside phosphorylase from calf spleen'''
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[[Category: Toms, A V.]]
[[Category: Toms, A V.]]
[[Category: Wang, W.]]
[[Category: Wang, W.]]
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[[Category: multisubstrate analog inhibitor]]
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[[Category: Multisubstrate analog inhibitor]]
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[[Category: purine nucleoside phosphorylase]]
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[[Category: Purine nucleoside phosphorylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:04:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:52:59 2008''
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Revision as of 16:04, 3 May 2008

Image:2ai2.gif

Template:STRUCTURE 2ai2

Purine nucleoside phosphorylase from calf spleen


Overview

In an effort to develop potent multisubstrate-analog inhibitors of purine nucleoside phosphorylase (PNP), three nucleoside phosphonates were designed utilizing structural information from the previously reported structures of complexes of bovine PNP with substrates and products. The nucleoside phosphonates contain an acetal linkage at the O2' and O3' positions and a two-C-atom spacer between the ribose and phosphate moieties. The linkage enables the compounds to simultaneously occupy the purine-, ribose- and phosphate-binding sites. The chemical syntheses, inhibition profiles and structural characterization of these novel multisubstrate analog inhibitors with bovine PNP are described.

About this Structure

2AI2 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase., Toms AV, Wang W, Li Y, Ganem B, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1449-58. Epub 2005, Oct 19. PMID:16239721 Page seeded by OCA on Sat May 3 19:04:40 2008

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