2aka

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[[Image:2aka.gif|left|200px]]
[[Image:2aka.gif|left|200px]]
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{{Structure
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|PDB= 2aka |SIZE=350|CAPTION= <scene name='initialview01'>2aka</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2aka", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= MHCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum]), Dnm1, Dnm ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_2aka| PDB=2aka | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aka OCA], [http://www.ebi.ac.uk/pdbsum/2aka PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2aka RCSB]</span>
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'''Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus'''
'''Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus'''
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[[Category: Schmid, S L.]]
[[Category: Schmid, S L.]]
[[Category: Vallee, R B.]]
[[Category: Vallee, R B.]]
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[[Category: dynamin]]
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[[Category: Dynamin]]
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[[Category: fusion protein]]
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[[Category: Fusion protein]]
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[[Category: gtpase domain]]
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[[Category: Gtpase domain]]
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[[Category: myosin]]
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[[Category: Myosin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:09:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:53:53 2008''
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Revision as of 16:09, 3 May 2008

Image:2aka.gif

Template:STRUCTURE 2aka

Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus


Overview

Here, we present the 1.9-A crystal structure of the nucleotide-free GTPase domain of dynamin 1 from Rattus norvegicus. The structure corresponds to an extended form of the canonical GTPase fold observed in Ras proteins. Both nucleotide-binding switch motifs are well resolved, adopting conformations that closely resemble a GTP-bound state not previously observed for nucleotide-free GTPases. Two highly conserved arginines, Arg-66 and Arg-67, greatly restrict the mobility of switch I and are ideally positioned to relay information about the nucleotide state to other parts of the protein. Our results support a model in which switch I residue Arg-59 gates GTP binding in an assembly-dependent manner and the GTPase effector domain functions as an assembly-dependent GTPase activating protein in the fashion of RGS-type GAPs.

About this Structure

2AKA is a Protein complex structure of sequences from Dictyostelium discoideum and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the GTPase domain of rat dynamin 1., Reubold TF, Eschenburg S, Becker A, Leonard M, Schmid SL, Vallee RB, Kull FJ, Manstein DJ, Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13093-8. Epub 2005 Sep 2. PMID:16141317 Page seeded by OCA on Sat May 3 19:09:05 2008

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