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2akr
From Proteopedia
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[[Image:2akr.gif|left|200px]] | [[Image:2akr.gif|left|200px]] | ||
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'''Structural basis of sulfatide presentation by mouse CD1d''' | '''Structural basis of sulfatide presentation by mouse CD1d''' | ||
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[[Category: Wu, D.]] | [[Category: Wu, D.]] | ||
[[Category: Zajonc, D M.]] | [[Category: Zajonc, D M.]] | ||
| - | [[Category: | + | [[Category: Cd1d]] |
| - | [[Category: | + | [[Category: Mhc fold]] |
| - | [[Category: | + | [[Category: Nkt cell]] |
| - | [[Category: | + | [[Category: Self-antigen]] |
| - | [[Category: | + | [[Category: Sulfatide]] |
| - | [[Category: | + | [[Category: Tcr]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:10:17 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 16:10, 3 May 2008
Structural basis of sulfatide presentation by mouse CD1d
Overview
Sulfatide derived from the myelin stimulates a distinct population of CD1d-restricted natural killer T (NKT) cells. Cis-tetracosenoyl sulfatide is one of the immunodominant species in myelin as identified by proliferation, cytokine secretion, and CD1d tetramer staining. The crystal structure of mouse CD1d in complex with cis-tetracosenoyl sulfatide at 1.9 A resolution reveals that the longer cis-tetracosenoyl fatty acid chain fully occupies the A' pocket of the CD1d binding groove, whereas the sphingosine chain fills up the F' pocket. A precise hydrogen bond network in the center of the binding groove orients and positions the ceramide backbone for insertion of the lipid tails in their respective pockets. The 3'-sulfated galactose headgroup is highly exposed for presentation to the T cell receptor and projects up and away from the binding pocket due to its beta linkage, compared with the more intimate binding of the alpha-glactosyl ceramide headgroup to CD1d. These structure and binding data on sulfatide presentation by CD1d have important implications for the design of therapeutics that target T cells reactive for myelin glycolipids in autoimmune diseases of the central nervous system.
About this Structure
2AKR is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity., Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA, J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 Page seeded by OCA on Sat May 3 19:10:17 2008
Categories: Mus musculus | Protein complex | Halder, R. | Kumar, V. | Maricic, I. | Roy, K. | Wilson, I A. | Wong, C H. | Wu, D. | Zajonc, D M. | Cd1d | Mhc fold | Nkt cell | Self-antigen | Sulfatide | Tcr
