2alx

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[[Image:2alx.gif|left|200px]]
[[Image:2alx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2alx |SIZE=350|CAPTION= <scene name='initialview01'>2alx</scene>, resolution 2.600&Aring;
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The line below this paragraph, containing "STRUCTURE_2alx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= nrdB, ftsB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_2alx| PDB=2alx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2alx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2alx OCA], [http://www.ebi.ac.uk/pdbsum/2alx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2alx RCSB]</span>
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}}
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'''Ribonucleotide Reductase R2 from Escherichia coli in space group P6(1)22'''
'''Ribonucleotide Reductase R2 from Escherichia coli in space group P6(1)22'''
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[[Category: Saleh, L.]]
[[Category: Saleh, L.]]
[[Category: Sommerhalter, M.]]
[[Category: Sommerhalter, M.]]
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[[Category: diiron center]]
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[[Category: Diiron center]]
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[[Category: dimanganese center]]
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[[Category: Dimanganese center]]
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[[Category: new crystal form]]
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[[Category: New crystal form]]
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[[Category: ribonucleotide reductase r2]]
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[[Category: Ribonucleotide reductase r2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:12:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:54:20 2008''
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Revision as of 16:12, 3 May 2008

Image:2alx.gif

Template:STRUCTURE 2alx

Ribonucleotide Reductase R2 from Escherichia coli in space group P6(1)22


Overview

A new crystal form of wild-type ribonucleotide reductase R2 from Escherichia coli was obtained. Crystals grow in space group P6(1)22 with one R2 monomer in the asymmetric unit. A twofold crystallographic symmetry axis generates the physiological dimeric form of R2. Co-crystallization with CoCl(2) or MnCl(2) results in full occupancy of the dinuclear metal site. The structure of the Mn(II)-loaded form was determined to 2.6 Angstroms resolution by molecular replacement. The crystallization conditions, backbone conformation, crystal-packing interactions and metal centers are compared with those of previously determined crystal forms.

About this Structure

2ALX is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of Escherichia coli ribonucleotide reductase R2 in space group P6122., Sommerhalter M, Saleh L, Bollinger JM Jr, Rosenzweig AC, Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1649-54. Epub 2005, Nov 19. PMID:16301799 Page seeded by OCA on Sat May 3 19:12:05 2008

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