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2alv

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[[Image:2alv.gif|left|200px]]
[[Image:2alv.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2alv |SIZE=350|CAPTION= <scene name='initialview01'>2alv</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2alv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CY6:N-((3S,6R)-6-((S,E)-4-ETHOXYCARBONYL-1-((S)-2-OXOPYRROLIDIN-3-YL)BUT-3-EN-2-YLCARBAMOYL)-2,9-DIMETHYL-4-OXODEC-8-EN-3-YL)-5-METHYLISOXAZOLE-3-CARBOXAMIDE'>CY6</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2alv| PDB=2alv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2alv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2alv OCA], [http://www.ebi.ac.uk/pdbsum/2alv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2alv RCSB]</span>
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}}
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'''X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors'''
'''X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors'''
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[[Category: 3cl]]
[[Category: 3cl]]
[[Category: 3clpro]]
[[Category: 3clpro]]
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[[Category: anti-viral]]
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[[Category: Anti-viral]]
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[[Category: coronavirus]]
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[[Category: Coronavirus]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: proteinase]]
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[[Category: Proteinase]]
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[[Category: sar]]
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[[Category: Sar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:12:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:54:22 2008''
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Revision as of 16:12, 3 May 2008

Image:2alv.gif

Template:STRUCTURE 2alv

X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors


Overview

Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.

About this Structure

2ALV is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors., Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD, J Med Chem. 2005 Nov 3;48(22):6767-71. PMID:16250632 Page seeded by OCA on Sat May 3 19:12:05 2008

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OCA

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