2atp

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[[Image:2atp.gif|left|200px]]
[[Image:2atp.gif|left|200px]]
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{{Structure
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|PDB= 2atp |SIZE=350|CAPTION= <scene name='initialview01'>2atp</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_2atp", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= Cd8a, Lyt-2, Lyt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Cd8b, Lyt-3, Lyt3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_2atp| PDB=2atp | SCENE= }}
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|RELATEDENTRY=[[1bqh|1BQH]], [[1nez|1NEZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2atp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atp OCA], [http://www.ebi.ac.uk/pdbsum/2atp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2atp RCSB]</span>
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'''Crystal structure of a CD8ab heterodimer'''
'''Crystal structure of a CD8ab heterodimer'''
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[[Category: Wang, J H.]]
[[Category: Wang, J H.]]
[[Category: Wang, X.]]
[[Category: Wang, X.]]
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[[Category: cd8aa]]
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[[Category: Cd8aa]]
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[[Category: cd8ab]]
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[[Category: Cd8ab]]
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[[Category: mhc]]
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[[Category: Mhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:27:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:57:13 2008''
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Revision as of 16:27, 3 May 2008

Image:2atp.gif

Template:STRUCTURE 2atp

Crystal structure of a CD8ab heterodimer


Overview

The crystal structure of a recombinant mouse single chain CD8alphabeta ectodomains at 2.4 A resolution reveals paired immunoglobulin variable region-like domains with a striking resemblance to CD8alphaalpha in size, shape, and surface electrostatic potential of complementarity-determining regions (CDR), despite <20% sequence identity between the CD8alpha and CD8beta subunits. Unlike the CD8alpha subunit(s) in the heterodimer or homodimer, the CDR1 loop of CD8beta tilts away from its corresponding CDR2 and CDR3 loops. Consistent with this observation, independent mutational studies reveal that alanine substitutions of residues in the CDR1 loop of CD8beta have no effect on CD8alphabeta coreceptor function, whereas mutations in CD8beta CDR2 and CDR3 loops abolish CD8alphabeta coreceptor activity. The implications of these findings and additional CD8alpha mutational studies for CD8alphabeta- versus CD8alphaalpha-MHCI binding are discussed.

About this Structure

2ATP is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer., Chang HC, Tan K, Ouyang J, Parisini E, Liu JH, Le Y, Wang X, Reinherz EL, Wang JH, Immunity. 2005 Dec;23(6):661-71. PMID:16356863 Page seeded by OCA on Sat May 3 19:27:51 2008

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