2ax0

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[[Image:2ax0.gif|left|200px]]
[[Image:2ax0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ax0 |SIZE=350|CAPTION= <scene name='initialview01'>2ax0</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2ax0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=5X:5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE'>5X</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2ax0| PDB=2ax0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ax0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ax0 OCA], [http://www.ebi.ac.uk/pdbsum/2ax0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ax0 RCSB]</span>
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}}
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'''Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)'''
'''Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)'''
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[[Category: Wang, Z.]]
[[Category: Wang, Z.]]
[[Category: Ye, Q.]]
[[Category: Ye, Q.]]
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[[Category: finger]]
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[[Category: Finger]]
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[[Category: hcv]]
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[[Category: Hcv]]
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[[Category: ns5b]]
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[[Category: Ns5b]]
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[[Category: palm]]
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[[Category: Palm]]
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[[Category: polymerase]]
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[[Category: Polymerase]]
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[[Category: thumb]]
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[[Category: Thumb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:34:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:58:23 2008''
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Revision as of 16:34, 3 May 2008

Image:2ax0.gif

Template:STRUCTURE 2ax0

Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)


Overview

Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases. The structures of the complexes formed between several of these inhibitors and HCV NS5b were determined by X-ray crystallography, and the inhibitors were found to bind in an allosteric binding site separate from the active site. Structure-activity relationships and structural studies have identified the mechanism of action for compounds in this series, several of which possess drug-like properties, as unique, reversible, covalent inhibitors of HCV NS5b.

About this Structure

2AX0 is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase., Powers JP, Piper DE, Li Y, Mayorga V, Anzola J, Chen JM, Jaen JC, Lee G, Liu J, Peterson MG, Tonn GR, Ye Q, Walker NP, Wang Z, J Med Chem. 2006 Feb 9;49(3):1034-46. PMID:16451069 Page seeded by OCA on Sat May 3 19:34:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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