2ayl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2ayl.gif|left|200px]]
[[Image:2ayl.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2ayl |SIZE=350|CAPTION= <scene name='initialview01'>2ayl</scene>, resolution 2.000&Aring;
+
The line below this paragraph, containing "STRUCTURE_2ayl", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=FLP:FLURBIPROFEN'>FLP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MNH:MANGANESE+PROTOPORPHYRIN+IX'>MNH</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2ayl| PDB=2ayl | SCENE= }}
-
|RELATEDENTRY=[[1q4g|1Q4G]], [[1eqh|1EQH]], [[1eqg|1EQG]], [[1ht5|1HT5]], [[1ht8|1HT8]], [[1prh|1PRH]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ayl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ayl OCA], [http://www.ebi.ac.uk/pdbsum/2ayl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ayl RCSB]</span>
+
-
}}
+
'''2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen'''
'''2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen'''
Line 29: Line 26:
[[Category: Loll, P J.]]
[[Category: Loll, P J.]]
[[Category: Selinsky, B S.]]
[[Category: Selinsky, B S.]]
-
[[Category: cyclooxygenase]]
+
[[Category: Cyclooxygenase]]
-
[[Category: egf-like domain]]
+
[[Category: Egf-like domain]]
-
[[Category: maganese protoporphyrin ix]]
+
[[Category: Maganese protoporphyrin ix]]
-
[[Category: membrane binding domain]]
+
[[Category: Membrane binding domain]]
-
[[Category: non-steroidal anti-inflammatory drug]]
+
[[Category: Non-steroidal anti-inflammatory drug]]
-
[[Category: peroxidase]]
+
[[Category: Peroxidase]]
-
[[Category: prostaglandin synthase]]
+
[[Category: Prostaglandin synthase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:37:50 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:59:04 2008''
+

Revision as of 16:37, 3 May 2008

Image:2ayl.gif

Template:STRUCTURE 2ayl

2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen


Overview

Prostaglandin H2 synthase (EC 1.14.99.1) is a clinically important drug target that catalyzes two key steps in the biosynthesis of the eicosanoid hormones. The enzyme contains spatially distinct cyclooxygenase and peroxidase active sites, both of which require a heme cofactor. Substitution of ferric heme by Mn(III) protoporphyrin IX greatly diminishes the peroxidase activity, but has little effect on the cyclooxygenase activity. Here, the 2.0 angstroms resolution crystal structure of the Mn(III) form of ovine prostaglandin H2 synthase-1 is described (R = 21.8%, R(free) = 23.7%). Substitution of Mn(III) for Fe(III) causes no structural perturbations in the protein. However, the out-of-plane displacement of the manganese ion with respect to the porphyrin is greater than that of the iron by approximately 0.2 angstroms. This perturbation may help to explain the altered catalytic properties of the manganese enzyme.

About this Structure

2AYL is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

Reference

2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor., Gupta K, Selinsky BS, Loll PJ, Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):151-6. Epub 2006, Jan 18. PMID:16421446 Page seeded by OCA on Sat May 3 19:37:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ayl"
Personal tools