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2ayp

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[[Image:2ayp.gif|left|200px]]
[[Image:2ayp.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ayp |SIZE=350|CAPTION= <scene name='initialview01'>2ayp</scene>, resolution 2.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2ayp", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=43A:(3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE'>43A</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CHEK1, CHK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2ayp| PDB=2ayp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ayp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ayp OCA], [http://www.ebi.ac.uk/pdbsum/2ayp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ayp RCSB]</span>
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}}
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'''Crystal Structure of CHK1 with an Indol Inhibitor'''
'''Crystal Structure of CHK1 with an Indol Inhibitor'''
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[[Category: Xia, P.]]
[[Category: Xia, P.]]
[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
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[[Category: protein-inhibitor complex]]
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[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:38:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:59:14 2008''
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Revision as of 16:38, 3 May 2008

Image:2ayp.gif

Template:STRUCTURE 2ayp

Crystal Structure of CHK1 with an Indol Inhibitor


Overview

Chk1 inhibitors have emerged as a novel class of neoplastic agents for abrogating the G2 DNA damage checkpoint arrest. Analogs of the Chk1 inhibitor, 3-ethylidene-1,3-dihydro-indol-2-one, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 28, which possesses potent enzymatic and cellular activities.

About this Structure

2AYP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors., Lin NH, Xia P, Kovar P, Park C, Chen Z, Zhang H, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. Epub 2005 Oct 18. PMID:16242328 Page seeded by OCA on Sat May 3 19:38:07 2008

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