2ayr

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[[Image:2ayr.gif|left|200px]]
[[Image:2ayr.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ayr |SIZE=350|CAPTION= <scene name='initialview01'>2ayr</scene>, resolution 1.900&Aring;
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The line below this paragraph, containing "STRUCTURE_2ayr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=L4G:6-(4-METHYLSULFONYL-PHENYL)-5-[4-(2-PIPERIDIN-1-YLETHOXY)PHENOXY]NAPHTHALEN-2-OL'>L4G</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= ESR1, ESR, NR3A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2ayr| PDB=2ayr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ayr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ayr OCA], [http://www.ebi.ac.uk/pdbsum/2ayr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ayr RCSB]</span>
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}}
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'''A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats'''
'''A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats'''
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[[Category: Wallace, O B.]]
[[Category: Wallace, O B.]]
[[Category: Wang, Y.]]
[[Category: Wang, Y.]]
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[[Category: ligand-binding]]
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[[Category: Ligand-binding]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: serm]]
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[[Category: Serm]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:38:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:59:07 2008''
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Revision as of 16:38, 3 May 2008

Image:2ayr.gif

Template:STRUCTURE 2ayr

A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats


Overview

The design of a novel selective estrogen receptor modulator (SERM) for the potential treatment of uterine leiomyoma is described. 16 (LY2066948-HCl) binds with high affinity to estrogen receptors alpha and beta (ERalpha and ERbeta, respectively) and is a potent uterine antagonist with minimal effects on the ovaries as determined by serum biomarkers and histologic evaluation.

About this Structure

2AYR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats., Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA, J Med Chem. 2005 Nov 3;48(22):6772-5. PMID:16250633 Page seeded by OCA on Sat May 3 19:38:16 2008

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OCA

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