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2az2

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[[Image:2az2.gif|left|200px]]
[[Image:2az2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2az2 |SIZE=350|CAPTION= <scene name='initialview01'>2az2</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2az2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=5BU:5-BROMO-URIDINE-5&#39;-MONOPHOSPHATE'>5BU</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 Flock house virus])
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-->
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|DOMAIN=
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{{STRUCTURE_2az2| PDB=2az2 | SCENE= }}
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|RELATEDENTRY=[[2az0|2AZ0]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2az2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2az2 OCA], [http://www.ebi.ac.uk/pdbsum/2az2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2az2 RCSB]</span>
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}}
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'''Flock House virus B2-dsRNA Complex (P4122)'''
'''Flock House virus B2-dsRNA Complex (P4122)'''
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[[Category: Schneemann, A.]]
[[Category: Schneemann, A.]]
[[Category: Williamson, J R.]]
[[Category: Williamson, J R.]]
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[[Category: four-helix bundle]]
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[[Category: Four-helix bundle]]
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[[Category: protein-rna complex]]
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[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:39:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:59:17 2008''
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Revision as of 16:39, 3 May 2008

Image:2az2.gif

Template:STRUCTURE 2az2

Flock House virus B2-dsRNA Complex (P4122)


Overview

As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.

About this Structure

2AZ2 is a Single protein structure of sequence from Flock house virus. Full crystallographic information is available from OCA.

Reference

Dual modes of RNA-silencing suppression by Flock House virus protein B2., Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR, Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:16228003 Page seeded by OCA on Sat May 3 19:39:02 2008

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