2eho
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(New page: 200px<br /> <applet load="2eho" size="450" color="white" frame="true" align="right" spinBox="true" caption="2eho, resolution 3.00Å" /> '''Crystal structure o...)
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Revision as of 19:43, 12 November 2007
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Crystal structure of human GINS complex
Contents |
Overview
The GINS complex mediates the assembly of the MCM2-7 (minichromosome, maintenance) complex with proteins in a replisome progression complex. The, eukaryotic GINS complex is composed of Sld5, Psf1, Psf2, and Psf3, which, must be assembled for cell proliferation. We determined the crystal, structure of the human GINS complex: GINS forms an elliptical shape with a, small central channel. The structures of Sld5 and Psf2 resemble those of, Psf1 and Psf3, respectively. In addition, the N-terminal and C-terminal, domains of Sld5/Psf1 are permuted in Psf2/Psf3, which suggests that the, four proteins have evolved from a common ancestor. Using a structure-based, mutational analysis, we identified the functionally critical surface, regions of the GINS complex.
Disease
Known diseases associated with this structure: Bare lymphocyte syndrome, type I OMIM:[170260], Bare lymphocyte syndrome, type I, due to TAP2 deficiency OMIM:[170261], Wegener-like granulomatosis OMIM:[170261]
About this Structure
2EHO is a Protein complex structure of sequences from Homo sapiens with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the human GINS complex., Choi JM, Lim HS, Kim JJ, Song OK, Cho Y, Genes Dev. 2007 Jun 1;21(11):1316-21. PMID:17545466
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