2azr

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[[Image:2azr.gif|left|200px]]
[[Image:2azr.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2azr |SIZE=350|CAPTION= <scene name='initialview01'>2azr</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_2azr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=982:3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC+ACID'>982</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2azr| PDB=2azr | SCENE= }}
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|RELATEDENTRY=[[2b07|2B07]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azr OCA], [http://www.ebi.ac.uk/pdbsum/2azr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2azr RCSB]</span>
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}}
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'''Crystal structure of PTP1B with Bicyclic Thiophene inhibitor'''
'''Crystal structure of PTP1B with Bicyclic Thiophene inhibitor'''
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[[Category: Xu, W X.]]
[[Category: Xu, W X.]]
[[Category: Zhang, Y L.]]
[[Category: Zhang, Y L.]]
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[[Category: bicyclic thiophene]]
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[[Category: Bicyclic thiophene]]
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[[Category: hydrolyase]]
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[[Category: Hydrolyase]]
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[[Category: protein tyrosine phosphatase]]
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[[Category: Protein tyrosine phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:40:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:59:31 2008''
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Revision as of 16:40, 3 May 2008

Image:2azr.gif

Template:STRUCTURE 2azr

Crystal structure of PTP1B with Bicyclic Thiophene inhibitor


Overview

A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallography and molecular modeling. Excellent consistency has been observed between structure-activity relationships and structural information from PTP1B-inhibitor complexes.

About this Structure

2AZR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors., Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J, Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. Epub 2005 Nov 21. PMID:16303309 Page seeded by OCA on Sat May 3 19:40:19 2008

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OCA

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