2b10

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2b10.gif|left|200px]]
[[Image:2b10.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2b10 |SIZE=350|CAPTION= <scene name='initialview01'>2b10</scene>, resolution 2.800&Aring;
+
The line below this paragraph, containing "STRUCTURE_2b10", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZNH:PROTOPORPHYRIN+IX+CONTAINING+ZN'>ZNH</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-c_peroxidase Cytochrome-c peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= CCP1, CCP, CPO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), CYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2b10| PDB=2b10 | SCENE= }}
-
|RELATEDENTRY=[[2b0z|2B0Z]], [[2b11|2B11]], [[2b12|2B12]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b10 OCA], [http://www.ebi.ac.uk/pdbsum/2b10 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b10 RCSB]</span>
+
-
}}
+
'''Crystal Structure of the Protein-Protein Complex between F82S cytochrome c and cytochrome c peroxidase'''
'''Crystal Structure of the Protein-Protein Complex between F82S cytochrome c and cytochrome c peroxidase'''
Line 28: Line 25:
[[Category: Crane, B R.]]
[[Category: Crane, B R.]]
[[Category: Kang, S A.]]
[[Category: Kang, S A.]]
-
[[Category: cytochrome]]
+
[[Category: Cytochrome]]
-
[[Category: electron transfer]]
+
[[Category: Electron transfer]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:43:13 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:59:58 2008''
+

Revision as of 16:43, 3 May 2008

Image:2b10.gif

Template:STRUCTURE 2b10

Crystal Structure of the Protein-Protein Complex between F82S cytochrome c and cytochrome c peroxidase


Overview

Although bonding networks determine electron-transfer (ET) rates within proteins, the mechanism by which structure and dynamics influence ET across protein interfaces is not well understood. Measurements of photochemically induced ET and subsequent charge recombination between Zn-porphyrin-substituted cytochrome c peroxidase and cytochrome c in single crystals correlate reactivity with defined structures for different association modes of the redox partners. Structures and ET rates in crystals are consistent with tryptophan oxidation mediating charge recombination reactions. Conservative mutations at the interface can drastically affect how the proteins orient and dispose redox centers. Whereas some configurations are ET inactive, the wild-type complex exhibits the fastest recombination rate. Other association modes generate ET rates that do not correlate with predictions based on cofactor separations or simple bonding pathways. Inhibition of photoinduced ET at <273 K indicates gating by small-amplitude dynamics, even within the crystal. Thus, different associations achieve states of similar reactivity, and within those states conformational fluctuations enable interprotein ET.

About this Structure

2B10 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Effects of interface mutations on association modes and electron-transfer rates between proteins., Kang SA, Crane BR, Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15465-70. Epub 2005 Oct 14. PMID:16227441 Page seeded by OCA on Sat May 3 19:43:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b10"
Personal tools