2b1o
From Proteopedia
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'''Solution Structure of Ca2+-bound DdCAD-1''' | '''Solution Structure of Ca2+-bound DdCAD-1''' | ||
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[[Category: Sriskanthadevan, S.]] | [[Category: Sriskanthadevan, S.]] | ||
[[Category: Yang, D W.]] | [[Category: Yang, D W.]] | ||
| - | [[Category: | + | [[Category: Calcium]] |
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| - | [[Category: | + | [[Category: Cell adhesion]] |
| - | [[Category: | + | [[Category: Ddcad-1]] |
| - | [[Category: | + | [[Category: Nmr]] |
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Revision as of 16:44, 3 May 2008
Solution Structure of Ca2+-bound DdCAD-1
Overview
DdCAD-1 is a novel Ca(2+)-dependent cell adhesion molecule that lacks a hydrophobic signal peptide and a transmembrane domain. DdCAD-1 is expressed by the social amoeba Dictyostelium discoideum at the onset of development. It is synthesized as a soluble protein and then transported to the plasma membrane by contractile vacuoles. Here we describe the novel features of the solution structures of Ca(2+)-free and Ca(2+)-bound monomeric DdCAD-1. DdCAD-1 contains two beta-sandwich domains, belonging to the betagamma-crystallin and immunoglobulin fold classes, respectively. Whereas the N-terminal domain has a major role in homophilic binding, the C-terminal domain tethers the protein to the cell membrane. From structural and mutational analyses, we propose a model for the Ca(2+)-bound DdCAD-1 dimer as a basis for understanding DdCAD-1-mediated cell-cell adhesion at the molecular level. Our results provide new insights into Ca(2+)-dependent mechanisms for cell-cell adhesion.
About this Structure
2B1O is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.
Reference
Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:17057715 Page seeded by OCA on Sat May 3 19:44:36 2008
