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2b2q

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[[Image:2b2q.gif|left|200px]]
[[Image:2b2q.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2b2q |SIZE=350|CAPTION= <scene name='initialview01'>2b2q</scene>, resolution 2.05&Aring;
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The line below this paragraph, containing "STRUCTURE_2b2q", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= katG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei])
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-->
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|DOMAIN=
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{{STRUCTURE_2b2q| PDB=2b2q | SCENE= }}
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|RELATEDENTRY=[[1mwv|1MWV]], [[2b2o|2B2O]], [[2b2r|2B2R]], [[2b2s|2B2S]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2q OCA], [http://www.ebi.ac.uk/pdbsum/2b2q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b2q RCSB]</span>
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}}
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'''Crystal structure of native catalase-peroxidase KATG AT pH7.5'''
'''Crystal structure of native catalase-peroxidase KATG AT pH7.5'''
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[[Category: Switala, J.]]
[[Category: Switala, J.]]
[[Category: Wiseman, B.]]
[[Category: Wiseman, B.]]
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[[Category: catalase-peroxidase]]
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[[Category: Catalase-peroxidase]]
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[[Category: katg]]
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[[Category: Katg]]
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[[Category: molecular switch]]
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[[Category: Molecular switch]]
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[[Category: ph change]]
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[[Category: Ph change]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:46:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:00:39 2008''
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Revision as of 16:46, 3 May 2008

Image:2b2q.gif

Template:STRUCTURE 2b2q

Crystal structure of native catalase-peroxidase KATG AT pH7.5


Overview

The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.

About this Structure

2B2Q is a Single protein structure of sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.

Reference

A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:16211084 Page seeded by OCA on Sat May 3 19:46:31 2008

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OCA

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