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2b3o

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[[Image:2b3o.gif|left|200px]]
[[Image:2b3o.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2b3o |SIZE=350|CAPTION= <scene name='initialview01'>2b3o</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_2b3o", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PTPN6, HCP, PTP1C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2b3o| PDB=2b3o | SCENE= }}
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|RELATEDENTRY=[[1gwz|1GWZ]], [[1fpr|1FPR]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3o OCA], [http://www.ebi.ac.uk/pdbsum/2b3o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b3o RCSB]</span>
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'''Crystal structure of human tyrosine phosphatase SHP-1'''
'''Crystal structure of human tyrosine phosphatase SHP-1'''
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[[Category: Zhao, Z J.]]
[[Category: Zhao, Z J.]]
[[Category: Zhou, G W.]]
[[Category: Zhou, G W.]]
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[[Category: protein tyrosine phosphatase]]
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[[Category: Protein tyrosine phosphatase]]
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[[Category: shp-1]]
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[[Category: Shp-1]]
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[[Category: signaling]]
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[[Category: Signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:48:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:00:59 2008''
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Revision as of 16:48, 3 May 2008

Image:2b3o.gif

Template:STRUCTURE 2b3o

Crystal structure of human tyrosine phosphatase SHP-1


Overview

SHP-1 is a cytosolic protein-tyrosine phosphatase that behaves as a negative regulator in eukaryotic cellular signaling pathways. To understand its regulatory mechanism, we have determined the crystal structure of the C-terminal truncated human SHP-1 in the inactive conformation at 2.8-A resolution and refined the structure to a crystallographic R-factor of 24.0%. The three-dimensional structure shows that the ligand-free SHP-1 has an auto-inhibited conformation. Its N-SH2 domain blocks the catalytic domain and keeps the enzyme in the inactive conformation, which supports that the phosphatase activity of SHP-1 is primarily regulated by the N-SH2 domain. In addition, the C-SH2 domain of SHP-1 has a different orientation from and is more flexible than that of SHP-2, which enables us to propose an enzymatic activation mechanism in which the C-SH2 domains of SHPs could be involved in searching for phosphotyrosine activators.

About this Structure

2B3O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human protein-tyrosine phosphatase SHP-1., Yang J, Liu L, He D, Song X, Liang X, Zhao ZJ, Zhou GW, J Biol Chem. 2003 Feb 21;278(8):6516-20. Epub 2002 Dec 13. PMID:12482860 Page seeded by OCA on Sat May 3 19:48:44 2008

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