2b53

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[[Image:2b53.gif|left|200px]]
[[Image:2b53.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2b53 |SIZE=350|CAPTION= <scene name='initialview01'>2b53</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2b53", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=D23:6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE'>D23</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2b53| PDB=2b53 | SCENE= }}
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|RELATEDENTRY=[[2b52|2B52]], [[2b54|2B54]], [[2b55|2B55]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b53 OCA], [http://www.ebi.ac.uk/pdbsum/2b53 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b53 RCSB]</span>
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}}
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'''Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325'''
'''Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Muckelbauer, J.]]
[[Category: Muckelbauer, J.]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: inhibition]]
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[[Category: Inhibition]]
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[[Category: mitosis]]
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[[Category: Mitosis]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protein kinase]]
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[[Category: Protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:51:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:01:37 2008''
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Revision as of 16:51, 3 May 2008

Image:2b53.gif

Template:STRUCTURE 2b53

Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325


Overview

Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.

About this Structure

2B53 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Quinazolines as cyclin dependent kinase inhibitors., Sielecki TM, Johnson TL, Liu J, Muckelbauer JK, Grafstrom RH, Cox S, Boylan J, Burton CR, Chen H, Smallwood A, Chang CH, Boisclair M, Benfield PA, Trainor GL, Seitz SP, Bioorg Med Chem Lett. 2001 May 7;11(9):1157-60. PMID:11354366 Page seeded by OCA on Sat May 3 19:51:56 2008

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OCA

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