2b7m

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[[Image:2b7m.gif|left|200px]]
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{{Structure
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|PDB= 2b7m |SIZE=350|CAPTION= <scene name='initialview01'>2b7m</scene>, resolution 3.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2b7m", creates the "Structure Box" on the page.
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|GENE= EXO70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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{{STRUCTURE_2b7m| PDB=2b7m | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7m OCA], [http://www.ebi.ac.uk/pdbsum/2b7m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b7m RCSB]</span>
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'''Crystal Structure of the S. cerevisiae Exocyst Component Exo70p'''
'''Crystal Structure of the S. cerevisiae Exocyst Component Exo70p'''
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[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
[[Category: West, A P.]]
[[Category: West, A P.]]
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[[Category: exocyst]]
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[[Category: Exocyst]]
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[[Category: exocytosis]]
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[[Category: Exocytosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:57:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:02:33 2008''
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Revision as of 16:57, 3 May 2008

Image:2b7m.gif

Template:STRUCTURE 2b7m

Crystal Structure of the S. cerevisiae Exocyst Component Exo70p


Overview

The exocyst is an evolutionarily conserved multiprotein complex required for the targeting and docking of post-Golgi vesicles to the plasma membrane. Through its interactions with a variety of proteins, including small GTPases, the exocyst is thought to integrate signals from the cell and signal that vesicles arriving at the plasma membrane are ready for fusion. Here we describe the three-dimensional crystal structure of one of the components of the exocyst, Exo70p, from Saccharomyces cerevisiae at 3.5A resolution. Exo70p binds the small GTPase Rho3p in a GTP-dependent manner with an equilibrium dissociation constant of approximately 70 microM. Exo70p is an extended rod approximately 155 angstroms in length composed principally of alpha helices, and is a novel fold. The structure provides a first view of the Exo70 protein family and provides a framework to study the molecular function of this exocyst component.

About this Structure

2B7M is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the S.cerevisiae exocyst component Exo70p., Hamburger ZA, Hamburger AE, West AP Jr, Weis WI, J Mol Biol. 2006 Feb 10;356(1):9-21. Epub 2005 Nov 10. PMID:16359701 Page seeded by OCA on Sat May 3 19:57:25 2008

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