2b8h

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[[Image:2b8h.gif|left|200px]]
[[Image:2b8h.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2b8h |SIZE=350|CAPTION= <scene name='initialview01'>2b8h</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_2b8h", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2b8h| PDB=2b8h | SCENE= }}
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|RELATEDENTRY=[[1a14|1a14]], [[1nmb|1nmb]], [[1nmc|1nmc]], [[7nn9|7nn9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8h OCA], [http://www.ebi.ac.uk/pdbsum/2b8h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b8h RCSB]</span>
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}}
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'''A/NWS/whale/Maine/1/84 (H1N9) reassortant influenza virus neuraminidase'''
'''A/NWS/whale/Maine/1/84 (H1N9) reassortant influenza virus neuraminidase'''
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[[Category: Zhang, J G.]]
[[Category: Zhang, J G.]]
[[Category: 6-bladed beta-propeller]]
[[Category: 6-bladed beta-propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:58:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:02:50 2008''
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Revision as of 16:58, 3 May 2008

Image:2b8h.gif

Template:STRUCTURE 2b8h

A/NWS/whale/Maine/1/84 (H1N9) reassortant influenza virus neuraminidase


Overview

The X-ray structure of influenza virus neuraminidase (NA) isolated from whale, subtype N9, has been determined at 2.2 A resolution and contains a tetrameric protein in the asymmetric unit. In structures of NA determined previously, a calcium ion is observed to coordinate amino acids near the substrate-binding site. In three of the NA monomers determined here this calcium is absent, resulting in structural alterations near the substrate-binding site. These changes affect the conformation of residues that participate in several key interactions between the enzyme and substrate and provide at a molecular level the basis of the structural and functional role of calcium in substrate and inhibitor binding. Several sulfate ions were identified in complex with the protein. These are located in the active site, occupying the space reserved for the substrate (sialic acid) carboxylate, and in positions leading away from the substrate-binding site. These sites offer a new opportunity for the design of inhibitors of influenza virus NA.

About this Structure

2B8H is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

Structure of a calcium-deficient form of influenza virus neuraminidase: implications for substrate binding., Smith BJ, Huyton T, Joosten RP, McKimm-Breschkin JL, Zhang JG, Luo CS, Lou MZ, Labrou NE, Garrett TP, Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):947-52. Epub 2006, Aug 19. PMID:16929094 Page seeded by OCA on Sat May 3 19:58:48 2008

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