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2b8l

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[[Image:2b8l.gif|left|200px]]
[[Image:2b8l.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2b8l |SIZE=350|CAPTION= <scene name='initialview01'>2b8l</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_2b8l", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=5HA:N-[(1S,2R)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2-HYDROXYPROPYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N&#39;-[(1R)-1-PHENYLETHYL]ISOPHTHALAMIDE'>5HA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= BACE1, BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2b8l| PDB=2b8l | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8l OCA], [http://www.ebi.ac.uk/pdbsum/2b8l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b8l RCSB]</span>
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}}
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'''Crystal structure of human beta secretase complexed with inhibitor'''
'''Crystal structure of human beta secretase complexed with inhibitor'''
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[[Category: Kuo, L.]]
[[Category: Kuo, L.]]
[[Category: Munshi, S K.]]
[[Category: Munshi, S K.]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: bace]]
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[[Category: Bace]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:59:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:02:53 2008''
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Revision as of 16:59, 3 May 2008

Image:2b8l.gif

Template:STRUCTURE 2b8l

Crystal structure of human beta secretase complexed with inhibitor


Overview

We have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the beta-secretase inhibitor 7m which has an in vitro IC(50)=35 nM. The synthesis and biological activities of these compounds are described.

About this Structure

2B8L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformationally biased P3 amide replacements of beta-secretase inhibitors., Stachel SJ, Coburn CA, Steele TG, Crouthamel MC, Pietrak BL, Lai MT, Holloway MK, Munshi SK, Graham SL, Vacca JP, Bioorg Med Chem Lett. 2006 Feb;16(3):641-4. Epub 2005 Nov 2. PMID:16263281 Page seeded by OCA on Sat May 3 19:59:01 2008

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