This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2b8v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2b8v.gif|left|200px]]
[[Image:2b8v.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2b8v |SIZE=350|CAPTION= <scene name='initialview01'>2b8v</scene>, resolution 1.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_2b8v", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=3BN:3-BENZOYL-N-[(1S,2R)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2-HYDROXYPROPYL]-5-[METHYL(METHYLSULFONYL)AMINO]BENZAMIDE'>3BN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= BACE1, BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2b8v| PDB=2b8v | SCENE= }}
-
|RELATEDENTRY=[[1tqf|1TQF]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8v OCA], [http://www.ebi.ac.uk/pdbsum/2b8v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b8v RCSB]</span>
+
-
}}
+
'''Crystal structure of human Beta-secretase complexed with L-L000430,469'''
'''Crystal structure of human Beta-secretase complexed with L-L000430,469'''
Line 36: Line 33:
[[Category: Steele, T G.]]
[[Category: Steele, T G.]]
[[Category: Vacca, J P.]]
[[Category: Vacca, J P.]]
-
[[Category: aspartyl protease]]
+
[[Category: Aspartyl protease]]
-
[[Category: bace]]
+
[[Category: Bace]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:59:42 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:02:58 2008''
+

Revision as of 16:59, 3 May 2008

Image:2b8v.gif

Template:STRUCTURE 2b8v

Crystal structure of human Beta-secretase complexed with L-L000430,469


Overview

We have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the beta-secretase inhibitor 7m which has an in vitro IC(50)=35 nM. The synthesis and biological activities of these compounds are described.

About this Structure

2B8V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformationally biased P3 amide replacements of beta-secretase inhibitors., Stachel SJ, Coburn CA, Steele TG, Crouthamel MC, Pietrak BL, Lai MT, Holloway MK, Munshi SK, Graham SL, Vacca JP, Bioorg Med Chem Lett. 2006 Feb;16(3):641-4. Epub 2005 Nov 2. PMID:16263281 Page seeded by OCA on Sat May 3 19:59:42 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b8v"
Personal tools