2bab

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[[Image:2bab.gif|left|200px]]
[[Image:2bab.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bab |SIZE=350|CAPTION= <scene name='initialview01'>2bab</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2bab", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ODD:(10E,12Z)-OCTADECA-10,12-DIENOIC+ACID'>ODD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bab| PDB=2bab | SCENE= }}
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|RELATEDENTRY=[[2b9w|2B9W]], [[2b9x|2B9X]], [[2b9y|2B9Y]], [[2ba9|2BA9]], [[2bac|2BAC]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bab OCA], [http://www.ebi.ac.uk/pdbsum/2bab PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bab RCSB]</span>
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}}
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'''Crystal structure of CLA-producing fatty acid isomerase from P. acnes'''
'''Crystal structure of CLA-producing fatty acid isomerase from P. acnes'''
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[[Category: Liavonchanka, A.]]
[[Category: Liavonchanka, A.]]
[[Category: Rudolph, M G.]]
[[Category: Rudolph, M G.]]
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[[Category: conjugated linoleic acid]]
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[[Category: Conjugated linoleic acid]]
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[[Category: fad]]
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[[Category: Fad]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:02:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:03:28 2008''
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Revision as of 17:02, 3 May 2008

Image:2bab.gif

Template:STRUCTURE 2bab

Crystal structure of CLA-producing fatty acid isomerase from P. acnes


Overview

Conjugated linoleic acids (CLAs) affect body fat gain, carcinogenesis, insulin resistance, and lipid peroxidation in mammals. Several isomers of CLA exist, of which the (9Z, 11E) and (10E, 12Z) isomers have beneficial effects on human metabolism but are scarce in foods. Bacterial polyunsaturated fatty acid isomerases are promising biotechnological catalysts for CLA production. We describe six crystal structures of the Propionibacterium acnes polyunsaturated fatty acid isomerase PAI in apo- and product-bound forms. The three-domain flavoprotein has previously undescribed folds outside the FAD-binding site. Conformational changes in a hydrophobic channel toward the active site reveal a unique gating mechanism for substrate specificity. The geometry of the substrate-binding site explains the length preferences for C18 fatty acids. A catalytic mechanism for double-bond isomerization is formulated that may be altered to change substrate specificity for syntheses of rare CLAs from easily accessible precursors.

About this Structure

2BAB is a Single protein structure of sequence from Propionibacterium acnes. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of the Propionibacterium acnes polyunsaturated fatty acid isomerase., Liavonchanka A, Hornung E, Feussner I, Rudolph MG, Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2576-81. Epub 2006 Feb 13. PMID:16477020 Page seeded by OCA on Sat May 3 20:02:24 2008

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