2bcg

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[[Image:2bcg.gif|left|200px]]
[[Image:2bcg.gif|left|200px]]
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{{Structure
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|PDB= 2bcg |SIZE=350|CAPTION= <scene name='initialview01'>2bcg</scene>, resolution 1.48&Aring;
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The line below this paragraph, containing "STRUCTURE_2bcg", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GER:GERAN-8-YL+GERAN'>GER</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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|GENE= GDI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), YPT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_2bcg| PDB=2bcg | SCENE= }}
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|RELATEDENTRY=[[1ukv|1ukv]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bcg OCA], [http://www.ebi.ac.uk/pdbsum/2bcg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bcg RCSB]</span>
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'''Structure of doubly prenylated Ypt1:GDI complex'''
'''Structure of doubly prenylated Ypt1:GDI complex'''
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[[Category: Pylypenko, O.]]
[[Category: Pylypenko, O.]]
[[Category: Rak, A.]]
[[Category: Rak, A.]]
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[[Category: geranylgeranylation]]
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[[Category: Geranylgeranylation]]
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[[Category: rabgtpase]]
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[[Category: Rabgtpase]]
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[[Category: vesicular transport]]
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[[Category: Vesicular transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:06:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:04:21 2008''
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Revision as of 17:06, 3 May 2008

Image:2bcg.gif

Template:STRUCTURE 2bcg

Structure of doubly prenylated Ypt1:GDI complex


Overview

In eukaryotic cells Rab/Ypt GTPases represent a family of key membrane traffic controllers that associate with their targeted membranes via C-terminally conjugated geranylgeranyl groups. GDP dissociation inhibitor (GDI) is a general and essential regulator of Rab recycling that extracts prenylated Rab proteins from membranes at the end of their cycle of activity and facilitates their delivery to the donor membranes. Here, we present the structure of a complex between GDI and a doubly prenylated Rab protein. We show that one geranylgeranyl residue is deeply buried in a hydrophobic pocket formed by domain II of GDI, whereas the other lipid is more exposed to solvent and is skewed across several atoms of the first moiety. Based on structural information and biophysical measurements, we propose mechanistic and thermodynamic models for GDI and Rab escort protein-mediated interaction of RabGTPase with intracellular membranes.

About this Structure

2BCG is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling., Pylypenko O, Rak A, Durek T, Kushnir S, Dursina BE, Thomae NH, Constantinescu AT, Brunsveld L, Watzke A, Waldmann H, Goody RS, Alexandrov K, EMBO J. 2006 Jan 11;25(1):13-23. Epub 2006 Jan 5. PMID:16395334 Page seeded by OCA on Sat May 3 20:06:24 2008

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