2bcj

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[[Image:2bcj.gif|left|200px]]
[[Image:2bcj.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bcj |SIZE=350|CAPTION= <scene name='initialview01'>2bcj</scene>, resolution 3.061&Aring;
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The line below this paragraph, containing "STRUCTURE_2bcj", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/[Beta-adrenergic-receptor]_kinase [Beta-adrenergic-receptor] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.15 2.7.11.15] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ADRBK1, GRK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]), Gnaq ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Rattus norvegicus,Mus musculus])
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|DOMAIN=
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{{STRUCTURE_2bcj| PDB=2bcj | SCENE= }}
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|RELATEDENTRY=[[1omw|1OMW]], [[1ym7|1YM7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bcj OCA], [http://www.ebi.ac.uk/pdbsum/2bcj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bcj RCSB]</span>
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}}
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'''Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits'''
'''Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Rattus norvegicus,mus musculus]]
[[Category: Rattus norvegicus,mus musculus]]
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[[Category: [Beta-adrenergic-receptor] kinase]]
 
[[Category: Tesmer, J J.G.]]
[[Category: Tesmer, J J.G.]]
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[[Category: heterotrimeric g protein]]
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[[Category: Heterotrimeric g protein]]
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[[Category: peripheral membrane complex]]
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[[Category: Peripheral membrane complex]]
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[[Category: protein kinase]]
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[[Category: Protein kinase]]
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[[Category: rgs domain]]
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[[Category: Rgs domain]]
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[[Category: wd40 protein]]
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[[Category: Wd40 protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:06:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:04:22 2008''
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Revision as of 17:06, 3 May 2008

Image:2bcj.gif

Template:STRUCTURE 2bcj

Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits


Overview

G protein-coupled receptor kinase 2 (GRK2) plays a key role in the desensitization of G protein-coupled receptor signaling by phosphorylating activated heptahelical receptors and by sequestering heterotrimeric G proteins. We report the atomic structure of GRK2 in complex with Galphaq and Gbetagamma, in which the activated Galpha subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer. Galphaq forms an effector-like interaction with the GRK2 regulator of G protein signaling (RGS) homology domain that is distinct from and does not overlap with that used to bind RGS proteins such as RGS4.

About this Structure

2BCJ is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus,mus musculus. Full crystallographic information is available from OCA.

Reference

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex., Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ, Science. 2005 Dec 9;310(5754):1686-90. PMID:16339447 Page seeded by OCA on Sat May 3 20:06:47 2008

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