This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2bdl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2bdl.gif|left|200px]]
[[Image:2bdl.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2bdl |SIZE=350|CAPTION= <scene name='initialview01'>2bdl</scene>, resolution 2.0&Aring;
+
The line below this paragraph, containing "STRUCTURE_2bdl", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=4PR:(3S)-1-{[(3,5-DIMETHYLISOXAZOL-4-YL)AMINO]CARBONYL}-4,4-DIMETHYLPYRROLIDIN-3-YL{(1S)-1-[1-HYDROXY-2-OXO-2-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL]PENTYL}CARBAMATE'>4PR</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2bdl| PDB=2bdl | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdl OCA], [http://www.ebi.ac.uk/pdbsum/2bdl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bdl RCSB]</span>
+
-
}}
+
'''Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor'''
'''Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor'''
Line 27: Line 24:
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Shewchuk, L M.]]
[[Category: Shewchuk, L M.]]
-
[[Category: cathepsin]]
+
[[Category: Cathepsin]]
-
[[Category: catk]]
+
[[Category: Catk]]
-
[[Category: cato]]
+
[[Category: Cato]]
-
[[Category: cysteine protease]]
+
[[Category: Cysteine protease]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:08:40 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:04:48 2008''
+

Revision as of 17:08, 3 May 2008

Image:2bdl.gif

Template:STRUCTURE 2bdl

Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor


Overview

Starting from a potent pantolactone ketoamide cathepsin K inhibitor discovered from structural screening, conversion of the lactone scaffold to a pyrrolidine scaffold allowed exploration of the S(3) subsite of cathepsin K. Manipulation of P3 and P1' groups afforded potent inhibitors with drug-like properties.

About this Structure

2BDL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors., Barrett DG, Catalano JG, Deaton DN, Hassell AM, Long ST, Miller AB, Miller LR, Ray JA, Samano V, Shewchuk LM, Wells-Knecht KJ, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1735-9. Epub 2006 Jan 11. PMID:16376075 Page seeded by OCA on Sat May 3 20:08:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bdl"
Personal tools