2bgw

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[[Image:2bgw.gif|left|200px]]
[[Image:2bgw.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bgw |SIZE=350|CAPTION= <scene name='initialview01'>2bgw</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2bgw", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+D'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bgw| PDB=2bgw | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bgw OCA], [http://www.ebi.ac.uk/pdbsum/2bgw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bgw RCSB]</span>
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}}
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'''XPF FROM AEROPYRUM PERNIX, COMPLEX WITH DNA'''
'''XPF FROM AEROPYRUM PERNIX, COMPLEX WITH DNA'''
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[[Category: Rudolf, J.]]
[[Category: Rudolf, J.]]
[[Category: White, M F.]]
[[Category: White, M F.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: nucleotide excision repair]]
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[[Category: Nucleotide excision repair]]
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[[Category: structure specific endonuclease]]
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[[Category: Structure specific endonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:16:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:06:13 2008''
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Revision as of 17:16, 3 May 2008

Image:2bgw.gif

Template:STRUCTURE 2bgw

XPF FROM AEROPYRUM PERNIX, COMPLEX WITH DNA


Overview

The XPF/Mus81 structure-specific endonucleases cleave double-stranded DNA (dsDNA) within asymmetric branched DNA substrates and play an essential role in nucleotide excision repair, recombination and genome integrity. We report the structure of an archaeal XPF homodimer alone and bound to dsDNA. Superposition of these structures reveals a large domain movement upon binding DNA, indicating how the (HhH)(2) domain and the nuclease domain are coupled to allow the recognition of double-stranded/single-stranded DNA junctions. We identify two nonequivalent DNA-binding sites and propose a model in which XPF distorts the 3' flap substrate in order to engage both binding sites and promote strand cleavage. The model rationalises published biochemical data and implies a novel role for the ERCC1 subunit of eukaryotic XPF complexes.

About this Structure

2BGW is a Single protein structure of sequence from Aeropyrum pernix. Full crystallographic information is available from OCA.

Reference

Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition., Newman M, Murray-Rust J, Lally J, Rudolf J, Fadden A, Knowles PP, White MF, McDonald NQ, EMBO J. 2005 Mar 9;24(5):895-905. Epub 2005 Feb 17. PMID:15719018 Page seeded by OCA on Sat May 3 20:16:12 2008

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OCA

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