2bht

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[[Image:2bht.gif|left|200px]]
[[Image:2bht.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bht |SIZE=350|CAPTION= <scene name='initialview01'>2bht</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2bht", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bht| PDB=2bht | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bht OCA], [http://www.ebi.ac.uk/pdbsum/2bht PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bht RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE B'''
'''CRYSTAL STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE B'''
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[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
[[Category: Zocher, G E.]]
[[Category: Zocher, G E.]]
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[[Category: cysteine biosynthesis]]
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[[Category: Cysteine biosynthesis]]
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[[Category: plp-dependent enzyme]]
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[[Category: Plp-dependent enzyme]]
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[[Category: pyridoxal phosphate]]
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[[Category: Pyridoxal phosphate]]
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[[Category: pyridoxal-5'-phosphate]]
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[[Category: Pyridoxal-5'-phosphate]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:18:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:06:41 2008''
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Revision as of 17:18, 3 May 2008

Image:2bht.gif

Template:STRUCTURE 2bht

CRYSTAL STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE B


Overview

The enzyme O-acetylserine sulfhydrylase participates in the biosynthesis of l-cysteine in bacteria and plants. The structure of isoenzyme B (CysM) from Escherichia coli was established in a hexagonal crystal form at 2.7 A resolution (wild-type) and in a merohedrally twinned tetragonal crystal form at 2.1 A resolution (surface mutant). Structural superpositions revealed the variations with respect to isoenzyme A (CysK) and explained the different substrate specificities. A geometric model of the reaction catalyzed by CysM is proposed. Both isoenzymes are used for the production of l-amino acid derivatives as building blocks for the synthesis of peptides and peptidomimetic drugs. Since the structure of CysM revealed a remarkable main chain variation at the active center, it constitutes a further starting point for engineering mutants with novel substrate specificities.

About this Structure

2BHT is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the O-acetylserine sulfhydrylase isoenzyme CysM from Escherichia coli., Claus MT, Zocher GE, Maier TH, Schulz GE, Biochemistry. 2005 Jun 21;44(24):8620-6. PMID:15952768 Page seeded by OCA on Sat May 3 20:18:32 2008

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