2bj6
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2bj6.gif|left|200px]] | [[Image:2bj6.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2bj6", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_2bj6| PDB=2bj6 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID''' | '''CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2BJ6 is a [[Single protein]] structure | + | 2BJ6 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA]. |
==Reference== | ==Reference== | ||
| Line 29: | Line 26: | ||
[[Category: Saenger, W.]] | [[Category: Saenger, W.]] | ||
[[Category: Straeter, N.]] | [[Category: Straeter, N.]] | ||
| - | [[Category: | + | [[Category: Backbone modification]] |
| - | [[Category: | + | [[Category: Dna,rna,hna,hexitol nucleic acid,hybrid,duplex,modified nucleic acid,antisense]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:21:47 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:21, 3 May 2008
CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID
Overview
The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.
About this Structure
2BJ6 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130 Page seeded by OCA on Sat May 3 20:21:47 2008
