2bj9

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[[Image:2bj9.gif|left|200px]]
[[Image:2bj9.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bj9 |SIZE=350|CAPTION= <scene name='initialview01'>2bj9</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2bj9", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Pg4+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bj9| PDB=2bj9 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bj9 OCA], [http://www.ebi.ac.uk/pdbsum/2bj9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bj9 RCSB]</span>
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}}
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'''NIKR WITH BOUND NICKEL AND PHOSPHATE'''
'''NIKR WITH BOUND NICKEL AND PHOSPHATE'''
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Tahirov, T H.]]
[[Category: Tahirov, T H.]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: nickel]]
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[[Category: Nickel]]
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[[Category: nikr]]
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[[Category: Nikr]]
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[[Category: pyrococcus horikoshii]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: repressor]]
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[[Category: Repressor]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: Rsgi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:21:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:07:13 2008''
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Revision as of 17:21, 3 May 2008

Image:2bj9.gif

Template:STRUCTURE 2bj9

NIKR WITH BOUND NICKEL AND PHOSPHATE


Overview

The Pyrococcus horikoshii OT3 genome contains a gene (PH0601 or nikR) encoding a protein (PhNikR) that shares 33.8% amino acid sequence identity with Escherichia coli nickel responsive repressor NikR (EcNikR), including many residues that are functionally important in the E.coli ortholog. We succeeded in crystallization and structural characterization of PhNikR in the apo form and two nickel bound forms that exhibit different conformations, open and closed. Moreover, we have identified a putative "low-affinity" nickel-binding pocket in the closed form. This binding site has unusual nickel coordination and exhibits high sensitivity to phosphate in the crystal structure. Analysis of the PhNikR structures and structure-based mutational studies with EcNikR reveals a plausible mechanism of nickel-dependent promoter recognition by the NikR family of proteins.

About this Structure

2BJ9 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Structure of Pyrococcus horikoshii NikR: nickel sensing and implications for the regulation of DNA recognition., Chivers PT, Tahirov TH, J Mol Biol. 2005 May 6;348(3):597-607. PMID:15826657 Page seeded by OCA on Sat May 3 20:21:56 2008

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OCA

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