2bjf

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[[Image:2bjf.gif|left|200px]]
[[Image:2bjf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bjf |SIZE=350|CAPTION= <scene name='initialview01'>2bjf</scene>, resolution 1.67&Aring;
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The line below this paragraph, containing "STRUCTURE_2bjf", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DXC:(3ALPHA,5ALPHA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAU:2-AMINOETHANESULFONIC+ACID'>TAU</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bjf| PDB=2bjf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bjf OCA], [http://www.ebi.ac.uk/pdbsum/2bjf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bjf RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF CONJUGATED BILE ACID HYDROLASE FROM CLOSTRIDIUM PERFRINGENS IN COMPLEX WITH REACTION PRODUCTS TAURINE AND DEOXYCHOLATE'''
'''CRYSTAL STRUCTURE OF CONJUGATED BILE ACID HYDROLASE FROM CLOSTRIDIUM PERFRINGENS IN COMPLEX WITH REACTION PRODUCTS TAURINE AND DEOXYCHOLATE'''
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[[Category: Saenger, W.]]
[[Category: Saenger, W.]]
[[Category: Schultz-Heienbrok, R.]]
[[Category: Schultz-Heienbrok, R.]]
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[[Category: amidohydrolase]]
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[[Category: Amidohydrolase]]
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[[Category: bile acid]]
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[[Category: Bile acid]]
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[[Category: bsh]]
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[[Category: Bsh]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: ntn-hydrolase]]
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[[Category: Ntn-hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:22:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:07:19 2008''
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Revision as of 17:22, 3 May 2008

Image:2bjf.gif

Template:STRUCTURE 2bjf

CRYSTAL STRUCTURE OF CONJUGATED BILE ACID HYDROLASE FROM CLOSTRIDIUM PERFRINGENS IN COMPLEX WITH REACTION PRODUCTS TAURINE AND DEOXYCHOLATE


Overview

Bacterial bile salt hydrolases catalyze the degradation of conjugated bile acids in the mammalian gut. The crystal structures of conjugated bile acid hydrolase (CBAH) from Clostridium perfringens as apoenzyme and in complex with taurodeoxycholate that was hydrolyzed to the reaction products taurine and deoxycholate are described here at 2.1 and 1.7 A resolution, respectively. The crystal structures reveal close relationship between CBAH and penicillin V acylase from Bacillus sphaericus. This similarity together with the N-terminal cysteine classifies CBAH as a member of the N-terminal nucleophile (Ntn) hydrolase superfamily. Both crystal structures show an identical homotetrameric organization with dihedral (D(2) or 222) point group symmetry. The structure analysis of C. perfringens CBAH identifies critical residues in catalysis, substrate recognition, and tetramer formation which may serve in further biochemical characterization of bile acid hydrolases.

About this Structure

2BJF is a Single protein structure of sequence from Clostridium perfringens. Full crystallographic information is available from OCA.

Reference

Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product., Rossocha M, Schultz-Heienbrok R, von Moeller H, Coleman JP, Saenger W, Biochemistry. 2005 Apr 19;44(15):5739-48. PMID:15823032 Page seeded by OCA on Sat May 3 20:22:22 2008

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