2bks

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2bks.gif|left|200px]]
[[Image:2bks.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2bks |SIZE=350|CAPTION= <scene name='initialview01'>2bks</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_2bks", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Pz1+Binding+Site+For+Chain+A'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=PZ1:(6R)-6-({[1-(3-HYDROXYPROPYL)-1,7-DIHYDROQUINOLIN-7-YL]OXY}METHYL)-1-(4-{3-[(2-METHOXYBENZYL)OXY]PROPOXY}PHENYL)PIPERAZIN-2-ONE'>PZ1</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2bks| PDB=2bks | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bks OCA], [http://www.ebi.ac.uk/pdbsum/2bks PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bks RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX'''
'''CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX'''
Line 34: Line 31:
[[Category: Ryan, J M.]]
[[Category: Ryan, J M.]]
[[Category: Zhang, E.]]
[[Category: Zhang, E.]]
-
[[Category: aspartic proteinase]]
+
[[Category: Aspartic proteinase]]
-
[[Category: aspartyl protease]]
+
[[Category: Aspartyl protease]]
-
[[Category: glycoprotein]]
+
[[Category: Glycoprotein]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: plasma]]
+
[[Category: Plasma]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: signal]]
+
[[Category: Signal]]
-
[[Category: zymogen]]
+
[[Category: Zymogen]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:25:35 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:07:53 2008''
+

Revision as of 17:25, 3 May 2008

Image:2bks.gif

Template:STRUCTURE 2bks

CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX


Overview

We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.

About this Structure

2BKS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327 Page seeded by OCA on Sat May 3 20:25:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bks"
Personal tools