2bky

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2bky.gif|left|200px]]
[[Image:2bky.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2bky |SIZE=350|CAPTION= <scene name='initialview01'>2bky</scene>, resolution 1.70&Aring;
+
The line below this paragraph, containing "STRUCTURE_2bky", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Mpd+Binding+Site+For+Chain+Y'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2bky| PDB=2bky | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bky OCA], [http://www.ebi.ac.uk/pdbsum/2bky PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bky RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF THE ALBA1:ALBA2 HETERODIMER FROM SULFOLOBUS SOLFATARICUS'''
'''CRYSTAL STRUCTURE OF THE ALBA1:ALBA2 HETERODIMER FROM SULFOLOBUS SOLFATARICUS'''
Line 32: Line 29:
[[Category: Waltho, J P.]]
[[Category: Waltho, J P.]]
[[Category: White, M F.]]
[[Category: White, M F.]]
-
[[Category: acetylation]]
+
[[Category: Acetylation]]
-
[[Category: archaeal dna binding protein]]
+
[[Category: Archaeal dna binding protein]]
-
[[Category: dna binding protein]]
+
[[Category: Dna binding protein]]
-
[[Category: dna condensation]]
+
[[Category: Dna condensation]]
-
[[Category: dna-binding]]
+
[[Category: Dna-binding]]
-
[[Category: rna-binding]]
+
[[Category: Rna-binding]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:25:58 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:07:55 2008''
+

Revision as of 17:26, 3 May 2008

Image:2bky.gif

Template:STRUCTURE 2bky

CRYSTAL STRUCTURE OF THE ALBA1:ALBA2 HETERODIMER FROM SULFOLOBUS SOLFATARICUS


Overview

Organisms growing at elevated temperatures face a particular challenge to maintain the integrity of their genetic material. All thermophilic and hyperthermophilic archaea encode one or more copies of the Alba (Sac10b) gene. Alba is an abundant, dimeric, highly basic protein that binds cooperatively and at high density to DNA. Sulfolobus solfataricus encodes a second copy of the Alba gene, and the Alba2 protein is expressed at approximately 5% of the level of Alba1. We demonstrate by NMR, ITC, and crystallography that Alba2 exists exclusively as a heterodimer with Alba1 at physiological concentrations and that heterodimerization exerts a clear effect upon the DNA packaging, as observed by EM, potentially by changing the interface between adjacent Alba dimers in DNA complexes. A functional role for Alba2 in modulation of higher order chromatin structure and DNA condensation is suggested.

About this Structure

2BKY is a Protein complex structure of sequences from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging., Jelinska C, Conroy MJ, Craven CJ, Hounslow AM, Bullough PA, Waltho JP, Taylor GL, White MF, Structure. 2005 Jul;13(7):963-71. PMID:16004869 Page seeded by OCA on Sat May 3 20:25:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bky"
Personal tools