2bo6

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[[Image:2bo6.gif|left|200px]]
[[Image:2bo6.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bo6 |SIZE=350|CAPTION= <scene name='initialview01'>2bo6</scene>, resolution 2.45&Aring;
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The line below this paragraph, containing "STRUCTURE_2bo6", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DGY:(2R)-2,3-DIHYDROXYPROPANOIC+ACID'>DGY</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2bo6| PDB=2bo6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bo6 OCA], [http://www.ebi.ac.uk/pdbsum/2bo6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bo6 RCSB]</span>
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}}
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'''DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE'''
'''DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE'''
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[[Category: Taylor, E.]]
[[Category: Taylor, E.]]
[[Category: Yang, M.]]
[[Category: Yang, M.]]
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[[Category: catalysis,glycosyltransferase,mannose,transferase]]
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[[Category: Catalysis,glycosyltransferase,mannose,transferase]]
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[[Category: stereoselectivity]]
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[[Category: Stereoselectivity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:33:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:15 2008''
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Revision as of 17:33, 3 May 2008

Image:2bo6.gif

Template:STRUCTURE 2bo6

DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE


Overview

The enzymatic transfer of activated mannose yields mannosides in glycoconjugates and oligo- and polysaccharides. Yet, despite its biological necessity, the mechanism by which glycosyltransferases recognize mannose and catalyze its transfer to acceptor molecules is poorly understood. Here, we report broad high-throughput screening and kinetic analyses of both natural and synthetic substrates of Rhodothermus marinus mannosylglycerate synthase (MGS), which catalyzes the formation of the stress protectant 2-O-alpha-D-mannosyl glycerate. The sequence of MGS indicates that it is at the cusp of inverting and retaining transferases. The structures of apo MGS and complexes with donor and acceptor molecules, including GDP-mannose, combined with mutagenesis of the binding and catalytic sites, unveil the mannosyl transfer center. Nucleotide specificity is as important in GDP-D-mannose recognition as the nature of the donor sugar.

About this Structure

2BO6 is a Single protein structure of sequence from Rhodothermus marinus. Full crystallographic information is available from OCA.

Reference

Structural dissection and high-throughput screening of mannosylglycerate synthase., Flint J, Taylor E, Yang M, Bolam DN, Tailford LE, Martinez-Fleites C, Dodson EJ, Davis BG, Gilbert HJ, Davies GJ, Nat Struct Mol Biol. 2005 Jul;12(7):608-14. Epub 2005 Jun 12. PMID:15951819 Page seeded by OCA on Sat May 3 20:33:40 2008

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