2bov

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2bov.gif|left|200px]]
[[Image:2bov.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2bov |SIZE=350|CAPTION= <scene name='initialview01'>2bov</scene>, resolution 2.66&Aring;
+
The line below this paragraph, containing "STRUCTURE_2bov", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+A'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2bov| PDB=2bov | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bov OCA], [http://www.ebi.ac.uk/pdbsum/2bov PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bov RCSB]</span>
+
-
}}
+
'''MOLECULAR RECOGNITION OF AN ADP-RIBOSYLATING CLOSTRIDIUM BOTULINUM C3 EXOENZYME BY RALA GTPASE'''
'''MOLECULAR RECOGNITION OF AN ADP-RIBOSYLATING CLOSTRIDIUM BOTULINUM C3 EXOENZYME BY RALA GTPASE'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
2BOV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1WCA. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOV OCA].
+
2BOV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wca 1wca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOV OCA].
==Reference==
==Reference==
Line 31: Line 28:
[[Category: Shone, C C.]]
[[Category: Shone, C C.]]
[[Category: Sutton, J M.]]
[[Category: Sutton, J M.]]
-
[[Category: adp]]
+
[[Category: Adp]]
-
[[Category: c3bot]]
+
[[Category: C3bot]]
-
[[Category: exoenzyme]]
+
[[Category: Exoenzyme]]
-
[[Category: glycosyltransferase]]
+
[[Category: Glycosyltransferase]]
-
[[Category: gtp-binding]]
+
[[Category: Gtp-binding]]
-
[[Category: gtpase]]
+
[[Category: Gtpase]]
-
[[Category: lipoprotein]]
+
[[Category: Lipoprotein]]
-
[[Category: nad]]
+
[[Category: Nad]]
-
[[Category: prenylation]]
+
[[Category: Prenylation]]
-
[[Category: rala]]
+
[[Category: Rala]]
-
[[Category: ribosylating toxin]]
+
[[Category: Ribosylating toxin]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:35:22 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:32 2008''
+

Revision as of 17:35, 3 May 2008

Image:2bov.gif

Template:STRUCTURE 2bov

MOLECULAR RECOGNITION OF AN ADP-RIBOSYLATING CLOSTRIDIUM BOTULINUM C3 EXOENZYME BY RALA GTPASE


Overview

C3 exoenzymes (members of the ADP-ribosyltranferase family) are produced by Clostridium botulinum (C3bot1 and -2), Clostridium limosum (C3lim), Bacillus cereus (C3cer), and Staphylococcus aureus (C3stau1-3). These exoenzymes lack a translocation domain but are known to specifically inactivate Rho GTPases in host target cells. Here, we report the crystal structure of C3bot1 in complex with RalA (a GTPase of the Ras subfamily) and GDP at a resolution of 2.66 A. RalA is not ADP-ribosylated by C3 exoenzymes but inhibits ADP-ribosylation of RhoA by C3bot1, C3lim, and C3cer to different extents. The structure provides an insight into the molecular interactions between C3bot1 and RalA involving the catalytic ADP-ribosylating turn-turn (ARTT) loop from C3bot1 and helix alpha4 and strand beta6 (which are not part of the GDP-binding pocket) from RalA. The structure also suggests a molecular explanation for the different levels of C3-exoenzyme inhibition by RalA and why RhoA does not bind C3bot1 in this manner.

About this Structure

2BOV is a Protein complex structure of sequences from Clostridium botulinum and Homo sapiens. This structure supersedes the now removed PDB entry 1wca. Full crystallographic information is available from OCA.

Reference

Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase., Holbourn KP, Sutton JM, Evans HR, Shone CC, Acharya KR, Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5357-62. Epub 2005 Apr 4. PMID:15809419 Page seeded by OCA on Sat May 3 20:35:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bov"
Personal tools