2bs0

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[[Image:2bs0.gif|left|200px]]
[[Image:2bs0.gif|left|200px]]
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{{Structure
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|PDB= 2bs0 |SIZE=350|CAPTION= <scene name='initialview01'>2bs0</scene>, resolution 2.45&Aring;
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The line below this paragraph, containing "STRUCTURE_2bs0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_2bs0| PDB=2bs0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bs0 OCA], [http://www.ebi.ac.uk/pdbsum/2bs0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bs0 RCSB]</span>
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}}
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'''MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX'''
'''MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX'''
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[[Category: Stonehouse, N J.]]
[[Category: Stonehouse, N J.]]
[[Category: Tars, K.]]
[[Category: Tars, K.]]
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[[Category: capsid]]
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[[Category: Capsid]]
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[[Category: coplex (capsid protein-rna hairpin)]]
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[[Category: Hairpin]]
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[[Category: hairpin]]
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[[Category: Icosahedral virus]]
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[[Category: icosahedral virus]]
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[[Category: Levivirus]]
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[[Category: levivirus]]
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[[Category: Rna-binding]]
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[[Category: rna-binding]]
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[[Category: Structural protein]]
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[[Category: structural protein]]
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[[Category: Virus coat protein]]
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[[Category: virus coat protein]]
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[[Category: Virus/viral protein/rna]]
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[[Category: virus/viral protein/rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:43:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:10:53 2008''
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Revision as of 17:43, 3 May 2008

Image:2bs0.gif

Template:STRUCTURE 2bs0

MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX


Overview

Sequence-specific interactions between RNA stem-loops and coat protein (CP) subunits play vital roles in the life cycles of the RNA bacteriophages, e.g., by allowing translational repression of their replicase cistrons and tagging their own RNA genomes for encapsidation. The CPs of bacteriophages Qbeta and MS2 each discriminate in favor of their cognate translational operators, even in the presence of closely related operators from other phages in vivo. Discrete mutations within the MS2 CP have been shown to relax this discrimination in vitro. We have determined the structures of eight complexes between such mutants and both MS2 and Qbeta stem-loops with X-ray crystallography. In conjunction with previously determined in vivo repression data, the structures enable us to propose the molecular basis for the discrimination mechanism.

About this Structure

2BS0 is a Protein complex structure of sequences from Enterobacterio phage ms2. Full crystallographic information is available from OCA.

Reference

Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2., Horn WT, Tars K, Grahn E, Helgstrand C, Baron AJ, Lago H, Adams CJ, Peabody DS, Phillips SE, Stonehouse NJ, Liljas L, Stockley PG, Structure. 2006 Mar;14(3):487-95. PMID:16531233 Page seeded by OCA on Sat May 3 20:43:00 2008

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