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2fbe
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(New page: 200px<br /> <applet load="2fbe" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fbe, resolution 2.52Å" /> '''Crystal Structure o...)
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Revision as of 19:56, 12 November 2007
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Crystal Structure of the PRYSPRY-domain
Overview
We determined the first structure of PRYSPRY, a domain found in over 500, different proteins, involved in innate immune signaling, cytokine, signaling suppression, development, cell growth and retroviral, restriction. The fold encompasses a 7-stranded and a 6-stranded, antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds, to the concave surface of a donor molecule, which represents a putative, interaction site. Mutations in the PRYSPRY domains of Pyrin, which are, responsible for familial Mediterranean fever, map on the putative PRYSPRY, interaction site.
About this Structure
2FBE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:16364311
Page seeded by OCA on Mon Nov 12 22:02:28 2007
