2bse
From Proteopedia
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'''STRUCTURE OF LACTOCOCCAL BACTERIOPHAGE P2 RECEPTOR BINDING PROTEIN IN COMPLEX WITH A LLAMA VHH DOMAIN''' | '''STRUCTURE OF LACTOCOCCAL BACTERIOPHAGE P2 RECEPTOR BINDING PROTEIN IN COMPLEX WITH A LLAMA VHH DOMAIN''' | ||
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[[Category: Spinelli, S.]] | [[Category: Spinelli, S.]] | ||
[[Category: Verrips, C T.]] | [[Category: Verrips, C T.]] | ||
| - | [[Category: | + | [[Category: Lactococcus lacti]] |
| - | [[Category: | + | [[Category: Llama antibody]] |
| - | [[Category: | + | [[Category: Phage]] |
| - | [[Category: | + | [[Category: Receptor]] |
| - | [[Category: | + | [[Category: Receptor binding protein]] |
| - | [[Category: | + | [[Category: Vhh]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:44:08 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:44, 3 May 2008
STRUCTURE OF LACTOCOCCAL BACTERIOPHAGE P2 RECEPTOR BINDING PROTEIN IN COMPLEX WITH A LLAMA VHH DOMAIN
Overview
Lactococcus lactis is a Gram-positive bacterium used extensively by the dairy industry for the manufacture of fermented milk products. The double-stranded DNA bacteriophage p2 infects specific L. lactis strains using a receptor-binding protein (RBP) located at the tip of its noncontractile tail. We have solved the crystal structure of phage p2 RBP, a homotrimeric protein composed of three domains: the shoulders, a beta-sandwich attached to the phage; the neck, an interlaced beta-prism; and the receptor-recognition head, a seven-stranded beta-barrel. We used the complex of RBP with a neutralizing llama VHH domain to identify the receptor-binding site. Structural similarity between the recognition-head domain of phage p2 and those of adenoviruses and reoviruses, which invade mammalian cells, suggests that these viruses, despite evolutionary distant targets, lack of sequence similarity and the different chemical nature of their genomes (DNA versus RNA), might have a common ancestral gene.
About this Structure
2BSE is a Protein complex structure of sequences from Lactococcus lactis phage p2 and Lama glama. Full crystallographic information is available from OCA.
Reference
Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses., Spinelli S, Desmyter A, Verrips CT, de Haard HJ, Moineau S, Cambillau C, Nat Struct Mol Biol. 2006 Jan;13(1):85-9. Epub 2005 Dec 4. PMID:16327804 Page seeded by OCA on Sat May 3 20:44:08 2008
