2bt4

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[[Image:2bt4.gif|left|200px]]
[[Image:2bt4.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bt4 |SIZE=350|CAPTION= <scene name='initialview01'>2bt4</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_2bt4", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Trs+Binding+Site+For+Chain+L'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA2:(1S,3R,4R,5S)-1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)CYCLOHEXANECARBOXYLIC+ACID'>CA2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bt4| PDB=2bt4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bt4 OCA], [http://www.ebi.ac.uk/pdbsum/2bt4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bt4 RCSB]</span>
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}}
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'''TYPE II DEHYDROQUINASE INHIBITOR COMPLEX'''
'''TYPE II DEHYDROQUINASE INHIBITOR COMPLEX'''
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[[Category: Stewart, K A.]]
[[Category: Stewart, K A.]]
[[Category: Toscano, M D.]]
[[Category: Toscano, M D.]]
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[[Category: amino-acid biosynthesis]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: aromatic amino acid biosynthesis]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: dehydroquinase]]
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[[Category: Dehydroquinase]]
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[[Category: dehydroquinate]]
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[[Category: Dehydroquinate]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: shikimate pathway]]
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[[Category: Shikimate pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:45:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:11:20 2008''
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Revision as of 17:45, 3 May 2008

Image:2bt4.gif

Template:STRUCTURE 2bt4

TYPE II DEHYDROQUINASE INHIBITOR COMPLEX


Overview

Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.

About this Structure

2BT4 is a Single protein structure of sequence from Streptomyces coelicolor. Full crystallographic information is available from OCA.

Reference

Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:16106291 Page seeded by OCA on Sat May 3 20:45:43 2008

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OCA

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