2buo

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[[Image:2buo.gif|left|200px]]
[[Image:2buo.gif|left|200px]]
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{{Structure
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|PDB= 2buo |SIZE=350|CAPTION= <scene name='initialview01'>2buo</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_2buo", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Acy+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>
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{{STRUCTURE_2buo| PDB=2buo | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2buo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2buo OCA], [http://www.ebi.ac.uk/pdbsum/2buo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2buo RCSB]</span>
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'''HIV-1 CAPSID C-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR OF PARTICLE ASSEMBLY'''
'''HIV-1 CAPSID C-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR OF PARTICLE ASSEMBLY'''
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[[Category: Sticht, J.]]
[[Category: Sticht, J.]]
[[Category: Ternois, F.]]
[[Category: Ternois, F.]]
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[[Category: assembly]]
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[[Category: Assembly]]
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[[Category: capsid]]
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[[Category: Capsid]]
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[[Category: complex (viral protein/peptide)]]
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[[Category: Hiv]]
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[[Category: hiv]]
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[[Category: Inhibitor]]
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[[Category: inhibitor]]
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[[Category: Polyprotein]]
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[[Category: polyprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:49:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:11:59 2008''
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Revision as of 17:49, 3 May 2008

Image:2buo.gif

Template:STRUCTURE 2buo

HIV-1 CAPSID C-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR OF PARTICLE ASSEMBLY


Overview

Immature HIV particles bud from infected cells after assembly at the cytoplasmic side of cellular membranes. This assembly is driven by interactions between Gag polyproteins. Mature particles, each containing a characteristic conical core, are later generated by proteolytic maturation of Gag in the virion. The C-terminal domain of the HIV-1 capsid protein (C-CA) has been shown to contain oligomerization determinants essential for particle assembly. Here we report the 1.7-A-resolution crystal structure of C-CA in complex with a peptide capable of inhibiting immature- and mature-like particle assembly in vitro. The peptide inserts as an amphipathic alpha-helix into a conserved hydrophobic groove of C-CA, resulting in formation of a compact five-helix bundle with altered dimeric interactions. This structure thus reveals the details of an allosteric site in the HIV capsid protein that can be targeted for antiviral therapy.

About this Structure

2BUO is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor., Ternois F, Sticht J, Duquerroy S, Krausslich HG, Rey FA, Nat Struct Mol Biol. 2005 Aug;12(8):678-82. Epub 2005 Jul 24. PMID:16041386 Page seeded by OCA on Sat May 3 20:49:28 2008

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